Pegylated interferon (PEG-INF) is a class of medication that includes three different drugs as of 2012: Pegylated interferon (PEG-INF) is a class of medication that includes three different drugs as of 2012: In these formulations, Polyethylene glycol (PEG) is added to make interferon last longer in the body. They are used to treat both hepatitis B, hepatitis C and multiple sclerosis.