Случай развития острого мегакариобластного лейкоза (M7) у больной с клинической ремиссией множественной миеломы

Acute megakaryoblastic leukemia is a rare and prognostic unfavorable variant of acute myeloid leukemia. As the incidence of this form is very low, no standard protocols of treatment are developed. Different induction and maintenance regiments of chemotherapy, hematopoietic stem cells transplantation are used. We describe a case of acute megakaryoblastic leukemia development in patient with a clinical remission of multiple myeloma, this report is unique as we did not found such a case described before. We suggest a relationship between acute leukemia development and antecedent chemotherapy for multiple myeloma. The patient achieved clinical remission of acute leukemia, clinical remission of multiple myeloma also continues. Now the patient receives maintenance chemotherapy.