Relative cytokines and their regulatory roles in megakaryocytopoiesis

It is a quite complex process that hematopoietic stem cells differentiate into megakaryocytes,which is composed of the mobilization of hematopoietic stem cell and differentiation into megakaryocyte progenitor cells,the proliferation of megakaryocyte progenitor cell,generation of mature megakaryocytes,megakaryocyte maturation and platelet release etc.It has been found that the mobilization of hematopoietic stem cell and the differentiation into most lineages are in a structure called "niche".A variety of signaling molecules involved in the regulation of hematopoietic stem cell mobilization and differentiation.This review is focus on several important cytokines participating in hematopoietic stem cell mobilization and megakaryocytopoiesis and their regulatory role in the niche.