PROTEIN KINASE C INHIBITORS : NOVEL SPIROSESQUITERPENE ALDEHYDES FROM A MARINE SPONGE AKA (=SIPHONODICTYON) CORALLIPHAGUM

: Two novel spirosesquiterpene aldehydes, corallidictyals A [1] and B [2], were isolated as a mixture from the marine sponge Aka (= Siphonodictyon) coralliphagum, and their structures were determined by detailed spectroscopic methods. These compounds were identified in a screen for inhibitors of protein kinase C.