Inhibitors phosphatidylinositol 3-kinase.

Compound of formula I ** ** Formula in free or salt form, wherein R1 is -CO-NRxRy, where Rx and Ry together with the nitrogen to which they are attached form a N-heterocyclic ring of 5 to 12 membered substituted or unsubstituted optionally including one or more ring heteroatoms selected from the group consisting of oxygen, nitrogen and sulfur, wherein optional substituents are selected from hydroxy, -SO2CH3 or aminocarbonyl; R2 is C1-C3; Y is carbon or nitrogen; and R3 and R4 are each independently hydrogen, halo, hydroxy, cyano, amino, carboxyl, (C1-C8) -sulfanilo, (C1-C8) alkylsulfinyl, (C1-C8) alkylsulfonyl, -SO2NH2, C1-C8 alkyl, C1-C8 alkyl, amino-C1-C8 alkyl, C1-C8 amino-, (C1-C8) alkylaminocarbonyl, di (C1-C8) alkylaminocarbonyl, di (C1-C8) -amino-C1-C8 alkyl, di (C1-C8) -amino-C1-C8 alkoxyl, (C1-C8 acyl) amino, aminocarbonyl, (C1-C8) alkoxycarbonyl, carboxy-C1- C8 alkyl, carboxy-C1-C8, C3-C15 carbocycle, a heterocyclic ring of 5 or 6 membered ring having one or more ring heteroatoms selected from the group consisting of oxygen, nitrogen and sulfur, (C1-C8) alkylamino or di (C1-C8) alkylamino, each being optionally substituted by amino, hydroxy, di (C1-C8) alkylamino or a heterocyclic 5- or 6-membered having one or more ring heteroatoms selected from the group It is consisting of oxygen, nitrogen and sulfur, or alkoxy C1-C8 optionally substituted with a heterocyclic ring of 5 or 6 membered ring having one or more ring heteroatoms selected from the group consisting of oxygen, nitrogen and sulfur.