MCLA-117, a CLEC12AxCD3 bispecific antibody targeting a leukaemic stem cell antigen, induces T cell-mediated AML blast lysis

Pieter Fokko van Loo,Basav N. Hangalapura,Soley Thordardottir,John D. Gibbins,Henrike Veninga,Linda Johanna Aleida Hendriks,Arjen Kramer,Rob Roovers,Marij Leenders,John de Kruif,Robert Doornbos,Andres Sirulnik,Mark Throsby,Ton Logtenberg,Harry Dolstra,Alexander Berthold Hendrik Bakker

MCLA-117, a CLEC12AxCD3 bispecific antibody targeting a leukaemic stem cell antigen, induces T cell-mediated AML blast lysis

2019

Pieter Fokko van Loo
Basav N. Hangalapura
Soley Thordardottir
John D. Gibbins
Henrike Veninga
Linda Johanna Aleida Hendriks
Arjen Kramer
Rob Roovers
Marij Leenders
John de Kruif
Robert Doornbos
Andres Sirulnik
Mark Throsby
Ton Logtenberg
Harry Dolstra
Alexander Berthold Hendrik Bakker

ABSTRACTObjective: We report the characterization of MCLA-117, a novel T cell-redirecting antibody for acute myeloid leukaemia (AML) treatment targeting CD3 on T cells and CLEC12A on leukaemic cell...

Keywords:

Medicine
Antibody
T cell
Immunology
Antigen
Cell
Cancer research
Myeloid
Lysis
Stem cell
CD3
Drug discovery

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