Hypophyseal hormones in young patients with breast cancer

: Hypophyseal hormones were studied in comparison with cellular and humoral immunity in young and middle aged females with breast cancer and controls matched by age. No correlation existed between LH concentrations and cellular, humoral immunological parameters in young breast cancer patients. Basal secretion of FSH directly correlated with the activation markers expression (antigens CD30, CD38) only in young patients. Prolactin concentration was negatively related to B-cell marker (mu-chain IgM) and expression of adhesion molecules (antigen CD11b) in the young, while in the middle-aged to mature T-cell levels only (antigen CD3). No age-specific correlations were found between immunological parameters and ACTH basal secretion, except direct relationship with CD11b-positive cells expression in middle-aged subjects.