Investigating the molecular mechanisms through which FTY720-P causes persistent S1P1 receptor internalization.
2014
Background and Purpose
The molecular mechanism underlying the clinical efficacy of FTY720-P is thought to involve persistent internalization and enhanced degradation of the S1P1 receptor subtype (S1P1R). We have investigated whether receptor binding kinetics and β-arrestin recruitment could play a role in the persistent internalization of the S1P1R by FTY720-P.
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