MicroRNA-128 coordinately targets Polycomb Repressor Complexes in glioma stem cells

Pierpaolo Peruzzi,Agnieszka Bronisz,Michał Nowicki,Yan Wang,Daisuke Ogawa,Richard L. Price,Ichiro Nakano,Chang-Hyuk Kwon,Josie Hayes,Sean E. Lawler,Michael C. Ostrowski,E. Antonio Chiocca,Jakub Godlewski

MicroRNA-128 coordinately targets Polycomb Repressor Complexes in glioma stem cells

2013

Pierpaolo Peruzzi
Agnieszka Bronisz
Michał Nowicki
Yan Wang
Daisuke Ogawa
Richard L. Price
Ichiro Nakano
Chang-Hyuk Kwon
Josie Hayes
Sean E. Lawler
Michael C. Ostrowski
E. Antonio Chiocca
Jakub Godlewski

Background The Polycomb Repressor Complex (PRC) is an epigenetic regulator of transcription whose action is mediated by 2 protein complexes, PRC1 and PRC2. PRC is oncogenic in glioblastoma, where it is involved in cancer stem cell maintenance and radioresistance.

Keywords:

PRC1
Cell biology
Immunology
PRC2
Radioresistance
microRNA
Stem cell
Repressor
Cancer stem cell
Biology
Polycomb-group proteins
Molecular biology
Neural stem cell
Gene knockdown
Glioma
SUZ12
BMI1

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