SUZ12

5IJ7, 5IJ8, 5HYN2351252615ENSG00000178691ENSMUSG00000017548Q15022Q80U70NM_015355NM_001321207NM_001163018NM_199196NP_001308136NP_056170NP_001156490NP_954666Polycomb protein SUZ12 is a protein that in humans is encoded by the SUZ12 gene. Polycomb protein SUZ12 is a protein that in humans is encoded by the SUZ12 gene. This zinc finger gene has been identified at the breakpoints of a recurrent chromosomal translocation reported in endometrial stromal sarcoma. Recombination of these breakpoints results in the fusion of this gene and JAZF1. The protein encoded by this gene contains a zinc finger domain in the C terminus of the coding region. The specific function of this gene has not yet been determined. SUZ12, as part of Polycomb Repressive Complex 2 (PRC2), may be involved with chromatin silencing in conjunction with HOTAIR ncRNA, using its zinc-finger domain to bind the RNA molecule.