ANT2681: SAR studies leading to the identification of a metallo-β-lactamase inhibitor with potential for clinical use in combination with meropenem for the treatment of infections caused by NDM-producing Enterobacteriaceae

David Davies,Simon Leiris,Nicolas Sprynski,Jerôme Castandet,Clarisse Lozano,Justine Bousquet,Magdalena Zalacain,srinivas vasa,Praveen Kumar Dasari,Ramesh Pattipati,Naresh Vempala,Swetha Gujjewar,syamkumar godi,raju jallala,Rajashekar Sathyap,Narasimha Darshanoju,Vengala Ravu,Ramakrishna Reddy Juventhala,Narender Pottabathini,Somesh Sharma,Srinivasu Pothukanuri,Kirsty Holden,Peter Warn,Francesca Marcoccia,Manuela Benvenuti,Cecilia Pozzi,Stefano Mangani,Jean Denis Docquier,Marc Lemonnier,Martin J. Everett

ANT2681: SAR studies leading to the identification of a metallo-β-lactamase inhibitor with potential for clinical use in combination with meropenem for the treatment of infections caused by NDM-producing Enterobacteriaceae

2020

The clinical effectiveness of the important β-lactam class of antibiotics is under threat by the emergence of resistance, mostly due to the production of acquired serine- (SBL) and metallo-β-lactam...

Keywords:

clinical effectiveness
Meropenem
Serine
Microbiology
metallo β lactamase
Antibiotics
Medicine
Enterobacteriaceae

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