Bone regeneration associated with low-level laser therapy in implantology

Several therapies for tissue regeneration in implantology have been explored for their ability to enhance bone regeneration such as low-level laser therapy (LLLT), also known as photobiomodulation. This technique has been shown to reduce inflammation and edema, induce analgesia, and promote healing in a range of musculoskeletal pathologies with cost-effective for healing therapy. The endothelial progenitor and hematopoietic stem cells, together with LLLT improving their capacity to induce angiogenesis, recruit other cells to a site of injury and secrete growth factors and cytokines that have a paracrine effect on surrounding cells. A critical review and comprehensively analyze of tissue regeneration associated to newer regenerative techniques as LLLT, platelet derivatives and mesenchymal stem cells (MSCs) at preimplant sites was released. An electronic search in PubMed via Medline and Embase was conducted of publications from the previous 10 years. English language articles related to the subject were found using selected keywords. We summarize the photobiomodulation properties and its relation with platelet derivatives and MSCs and discuss the efficacy of these therapies for tissue repair. The LLLT is well-documented therapy but further research studies relating LLLT to tissue regeneration in periodontics and implantology are needed.