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YO

Yasuo Ohno

Tohoku University

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Ken Nakazawa

Saitama Medical University

Kazuhide Inoue

Kyushu University

Makoto Usami

Muroran Institute of Technology

Akira Takanaka

Showa Pharmaceutical University

Shogo Ozawa

Aichi Gakuin University

Toru Kawanishi

Tokyo Institute of Technology

Atsuko Miyajima

National Institute of Health Sciences

Yoshiro Saito

National Institute of Health Sciences

Momoko Sunouchi

National Institute of Health Sciences

Kaoru Sato

National Institute of Health Sciences

Cooperative Institutions

National Institute of Health Sciences

The University of Tokyo

Osaka University

Kyoto University

National Institute of Health Sciences

Nagoya University

Tohoku University

Tokyo Medical and Dental University

Hokkaido University

Kyushu University

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Pharmacokinetic Study of Tris (2-chloroethyl) phosphate (TCEP) After Inhalation Exposure (Proceedings of the 22nd Symposium on Toxicology and Environmental Health)

Eisei kagaku (1997)

Kenji Yoshida Shinichi Ninomiya Yoshio ESUMI Hideo Kurebayashi KENICHIRO MINEGISHI

TCEP

10.1248/jhs1956.43.p9

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Citations (1)

THE SECOND PHASE VALIDATION STUDY OF ALTERNATIVE METHOD TO THE EYE IRRITATION TEST 8.Evaluation of Cytotoxicity Test in SIRC Cells

The Journal of Toxicological Sciences (1995)

Masato Hatao Noriko Murakami Kazutami Sakamoto Y. Takino M. Ohnuma

Eye irritation

Skin irritation

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The Synthesis of Cellulose by the Method of Organic Chemistry

Sen i Gakkaishi (1977)

10.2115/fiber.33.3_p87

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Citations (1)

Enhancement by cadmium ion of ATP-evoked responses in PC12 cells

The Japanese Journal of Pharmacology (1995)

Makoto Ikeda Schuichi Koizumi Ken Nakazawa Kaori Inoue Tomoko Obama

10.1016/s0021-5198(19)46593-1

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Citations (1)

Identification and characterization of lysophosphatidylcholine 14:0 as a biomarker for drug-induced lung disease

Scientific Reports (2022)

Kosuke Saito Akihiko Gemma Koichiro Tatsumi Noboru Hattori Atsuhito Ushiki

Abstract Drug-induced interstitial lung disease (DILD) occurs when drug exposure causes inflammation of the lung interstitium. DILD can be caused by different types of drugs, and some DILD patterns results in a high mortality rate; hence, DILD poses a serious problem in clinical practice as well as drug development, and strategies to diagnose and distinguish DILD from other lung diseases are necessary. We aimed to identify novel biomarkers for DILD by performing lipidomics analysis on plasma samples from patients with acute and recovery phase DILD. Having identified lysophosphatidylcholines (LPCs) as candidate biomarkers for DILD, we determined their concentrations using validated liquid chromatography/mass spectrometry biomarker assays. In addition, we evaluated the ability of LPCs to discriminate patients with acute phase DILD from those with recovery phase DILD, DILD-tolerant, or other lung diseases, and characterized their association with clinical characteristics. Lipidomics analysis revealed a clear decrease in LPC concentrations in the plasma of patients with acute phase DILD. In particular, LPC(14:0) had the highest discriminative index against recovery phase and DILD-tolerant patients. LPC(14:0) displayed no clear association with causal drugs, or subjects’ backgrounds, but was associated with disease severity. Furthermore, LPC(14:0) was able to discriminate between patients with DILD and other lung diseases, including idiopathic interstitial pneumonia and lung disease associated with connective tissue disease. LPC(14:0) is a promising biomarker for DILD that could improve the diagnosis of DILD and help to differentiate DILD from other lung diseases, such as idiopathic interstitial pneumonia and connective tissue disease.

10.1038/s41598-022-24406-z

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Citations (10)

On congruence properties of poly-Bernoulli numbers with negative upper-indices

arXiv (Cornell University) (2024)

Yasuo Ohno Mika Sakata

For any integer $k$, M.Kaneko defined $k$-th poly-Bernoulli numbers as a kind of generalization of classical Bernoulli numbers using $k$-th polylogarithm. In case when $k$ is positive, $k$-th poly-Bernoulli numbers is a sequence of rational numbers as same as classical Bernoulli numbers. On the other hand, in case when $k$ is negative, it is a sequence of positive integers, and many combinatoric and number theoretic properties has been investigated. In the present paper, the negative case is treated, and their congruence and $p$-adic properties are discussed. Beside of them, application of the results to obtain a congruence property for the number of lonesum matrices is also mentioned.

Congruence (geometry)

10.48550/arxiv.2409.18404

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Paper Industry in the1970's

Kobunshi (1972)

日本の製紙工業の現況をはあくし,将来を展望するため,まず,国際的視野から見た紙・パルプ企業の問題点, 次に他産業から見た製紙工業の特徴, について考察を試みた.最後に, 従来の製紙工業を, 二次元的シートをつくる工業(Sheet Makin gIndustry)として,広義の製紙工業へと発展させ,第一義的な脱紙・パルプ化を図るべきだとの提案を行なった。これは少しぎょうさんな表現をすれば,設備工業的色彩から総合化学的色彩への脱皮ともいえるであろう。

10.1295/kobunshi.21.3

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Multiple zeta values and connection formulas of Gauss's hypergeometric functions (Recent Trends in Microlocal Analysis)

数理解析研究所講究録 (2005)

Takashi Aoki Yasuo Ohno

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2. Non-clinical Data Needed for the Conduct of Microdose Clinical Study

Rinsho yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics (2009)

Microdose clinical study was introduced to Japan in June 2008 for the purpose of promoting new drug development. However, the upper dose of the study is below 100 μg and the application of findings to drug development is limited. On the other hand, the ICH-M3 guidance “Non-clinical safety studies for the conduct of human clinical trials for pharmaceuticals” was revised in June 2009, which introduces other approaches to exploratory clinical studies. The guidance describes five approaches (two microdose approaches, one sub-therapeutic single dose approach, and two up to therapeutic dose range repeated-dose approaches). Because the highest doses of these studies are limited to within the anticipated non-toxic dose ranges, requirement of toxicity tests is decreased compared to the classic phase 1 study. The rationales for the reduction of toxicity tests are explained.

MicroDose

Drug Development

Therapeutic index

10.3999/jscpt.41.9

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Studies of coagulation-fibrinolysis and kallikrein-kinin systems in the utero-placental circulation and amniotic fluid.

Blood & Vessel (1986)

S Mutoh Ansan TEH Y. Shimoji Nozomu Nishi M Saitoh

In 40 cases of full term pregnancey cesarean section performed before and during onset of labor. The amniotic fluid and blood samples from the uterine artery (U. A), uterine vein (U. V) and the peripheral vein (P. V) were collected and the changes of FPA, FPB β 15-42, HMW-kg, LMW-kg, glandular kallikrein and kinin were studied.The levels of FPA in UV increased significantly during onset of labor as compared to the increase in UA and PV and although the UV level of FPB β 15-42 also showed the same as that of FPA pattern of increase during labor but the increase was not so sharp. Levels of HMW- and LMW-kg gradually decreased during onset of labor but no significant differences among UV, UA and PV were found, Level of kinin in PV increased significantly during labor but remained unchanged in UV. In the amniotic fluid, the levels of FPA, FPB β 15-42, and HMW-kg increased gradually while that of kinin increased significantly and decreases of glandular kallikrein, LMW-kg and kininase II were seen during labor.These findings suggested that with the increased consumption of HMW- and LMW-kg and kinin during labor, the uteroplacental circulation exhibited a state of hypercoagulability with secondary hyperactivity of plasmin resulting in the increase in vascular permeability to the amniotic fluid and increased production of kinin.

10.2491/jjsth1970.17.51

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