Abeer M. Aljaadi

Umm al-Qura University

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Tim Green

South Australian Health and Medical Research Institute

Angela M. Devlin

University of British Columbia

Essra A. Noorwali

Umm al-Qura University

Rokayya Sami

Taif University

Melissa B. Glier

University of British Columbia

Mahmoud Helal

Taif University

Crystal D Karakochuk

British Columbia Children's Hospital

Joshua W. Miller

Rutgers, The State University of New Jersey

Rika E. Aleliunas

University of British Columbia

Hala Hazam Al-Otaibi

King Faisal University

Cooperative Institutions

Umm al-Qura University

Government College University, Faisalabad

University of British Columbia

National Research Centre

Tanta University

British Columbia Children's Hospital

King Abdulaziz University

National Water Research Center

Batterjee Medical College

Taif University

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Elsevier eBooks (2025)

Asmaa S. Abd Elkarim Howaida I. Abd‐Alla Yasmina M. Abd‐Elhakim Mosaad A. Abdel‐Wahhab Wafaa F. Abusudah

10.1016/b978-0-443-21820-0.00002-7

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Dietary Riboflavin Intake and Riboflavin Status in Young Adult Women Living in Metro Vancouver, Canada

Current Developments in Nutrition (2021)

Abeer M. Aljaadi Alejandra Wiedeman Susan I. Barr Angela M. Devlin Tim Green

Nutrition surveys suggest that <10% of Canadian adults have inadequate riboflavin intakes. However, biochemical riboflavin deficiency [erythrocyte glutathione reductase activity coefficient (EGRac) ≥1.40] has been reported in 41% of young adult women living in Metro Vancouver. Canadian Chinese ethnicity comprise >25% of Vancouver's population and are postulated to have poorer riboflavin status than those of European ethnicity because they could be less likely to consume dairy products and fortified wheat.

Glutathione reductase

10.1093/cdn/nzab021

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Citations (4)

Ultrasound-Assisted Extraction, LC–MS/MS Analysis, Anticholinesterase, and Antioxidant Activities of Valuable Natural Metabolites from Astragalus armatus Willd.: In Silico Molecular Docking and In Vitro Enzymatic Studies

Antioxidants (2022)

Sabrina Lekmine Samira Bendjedid Ouided Benslama A. I. Martín-García Samira Boussekine

The Astragalus armatus Willd. plant's phenolic constituent extraction and identification were optimized using the ultrasound-assisted extraction (UAE) method and the LC-MS/MS analysis, respectively. Additionally, cupric reducing antioxidant capacity (CUPRAC), beta carotene, reducing power, DMSO alcalin, silver nanoparticle (SNP)-based method, phenanthroline, and hydroxyl radical tests were utilized to assess the extract's antioxidant capacity, while the neuroprotective effect was examined in vitro against acetylcholinesterase enzyme. This study accurately estimated the chemical bonding between the identified phenolic molecules derived from LC-MS/MS and the AChE. The extract was found to contain sixteen phenolic substances, and rosmarinic, protocatechuic, and chlorogenic acids, as well as 4-hydroxybenzoic, hyperoside, and hesperidin, were the most abundant substances in the extract. In all antioxidant experiments, the plant extract demonstrated strong antioxidant activity and a significant inhibitory impact against AChE (40.25 ± 1.41 μg/mL). According to molecular docking affinity to the enzyme AChE, the top-five molecules were found to be luteolin, quercetin, naringenin, rosmarinic acid, and kaempferol. Furthermore, these tested polyphenols satisfy the essential requirements for drug-like characteristics and Lipinski's rule of five. These results highlight the significance of the A. armatus plant in cosmetics, as food additives, and in the pharmaceutical industry due to its rosmarinic and chlorogenic acid content.

Rosmarinic acid

Hyperoside

Chlorogenic Acid

Quercitrin

10.3390/antiox11102000

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Citations (14)

Contributors

Elsevier eBooks (2022)

Abrar Ahmad Rasheed Ahmad Muhammad Sajid Hamid Akash Rubab Akbar Abeer M. Aljaadi

10.1016/b978-0-323-95120-3.09995-4

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Comparison of a New Multiplex Immunoassay for Measurement of Ferritin, Soluble Transferrin Receptor, Retinol-Binding Protein, C-Reactive Protein and α1-Acid-glycoprotein Concentrations against a Widely-Used s-ELISA Method

Diagnostics (2018)

Crystal D Karakochuk Amanda Henderson Kaitlyn L. I. Samson Abeer M. Aljaadi Angela M. Devlin

Recently, a multiplex ELISA (Quansys Biosciences) was developed that measures ferritin, soluble transferrin receptor (sTfR), retinol-binding protein (RBP), C-reactive protein (CRP), α¹-acid glycoprotein (AGP), thyroglobulin, and histidine-rich protein 2. Our primary aim was to conduct a method-comparison study to compare five biomarkers (ferritin, sTfR, RBP, CRP, and AGP) measured with the Quansys assay and a widely-used s-ELISA (VitMin Lab, Willstaett, Germany) with use of serum samples from 180 women and children from Burkina Faso, Cambodia, and Malaysia. Bias and concordance were used to describe the agreement in values measured by the two methods. We observed poor overall agreement between the methods, both with regard to biomarker concentrations and deficiency prevalence estimates. Several measurements were outside of the limit of detection with use of the Quansys ELISA (total

Multiplex

Soluble transferrin receptor

Retinol binding protein

Nephelometry

Transferrin receptor

10.3390/diagnostics8010013

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Citations (6)

Programming of Glucose Homeostasis by Developmental Exposure to Folic Acid and Vitamin B12 Imbalance in Female Mice

Canadian Journal of Diabetes (2013)

Jesse D. Olson Rika E. Aleiunas Melissa B. Glier Abeer M. Aljaadi Tim Green

10.1016/j.jcjd.2013.08.213

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The Status of B Vitamin in Saudi Adults: A Review

Current Research in Nutrition and Food Science Journal (2023)

Abeer M. Aljaadi Fahdah F. Al-sunaid Maha Abdulrahim Najlaa H. Almehmadi Abeer Salman Alzaben

Background and Objective: B vitamins are essential for maintaining several body functions. Assessing micronutrient status in a population is crucial for evaluating the individual or the population’s levels of nutrient sufficiency, deficiency, or toxicity; examining the relationship between a nutrient’s status and adverse health outcomes; and determining nutrient needs to establish reference values. There is lack of periodical national surveys in Saudi Arabia that assess the status of the B vitamins. Therefore, this review summarizes and critique the literature of B vitamin status in Saudi adults age of ≥18 years. Methods and Study Design: Databases (PubMed, Medline and Google Scholar) were searched for articles published between January 1980 to December 2022 using combinations of the terms “Saudi Arabia”, “status”, “level” along with all the corresponding vitamin B keywords and metabolites. Results: Forty three studies were obtained. Only 28 studies were included to the current review. Several studies conducted in Saudi adults measured folate and vitamin B12 status. Fewer studies assessed thiamine, riboflavin, and pyridoxine status. No relevant studies were found on the status of niacin, pantothenic acid, and biotin. Studies on thiamin status have not reported rates of deficiency except for one study reporting a prevalence of 3%. Conflicting findings were observed for riboflavin status, but the most recent evidence suggests a prevalence of 36.9% deficiency among Saudi adults. Folate deficiency appears to be low, whereas vitamin B12 might be of concern among Saudi adults. Conclusions: There were discrepancies in the results of some vitamin status in Saudi adults mainly attributed to differences in biomarkers used, methodologies, regional differences, and/or age group/population.

Niacin

Pantothenic acid

10.12944/crnfsj.11.3.01

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Riboflavin intake and status and relationship to anemia

Nutrition Reviews (2022)

Abeer M. Aljaadi Angela M. Devlin Tim Green

Abstract Riboflavin in its coenzyme forms, flavin mononucleotide and flavin adenine dinucleotide, is essential for multiple redox reactions necessary for energy production, antioxidant protection, and metabolism of other B vitamins, such as niacin, pyridoxine, and folate. Erythrocyte glutathione reductase activity coefficient (EGRac) is a biomarker of riboflavin status; ratios ≥1.40 are commonly interpreted as indicating biochemical deficiency. Most research on riboflavin status comes from low-income countries and rural settings, which reported high rates of riboflavin deficiency and inadequate intake. However, some studies suggest that riboflavin deficiency, based on the functional indicator EGRac, is also of concern in middle- and high-income countries. Biochemical riboflavin deficiency that does not cause clinical symptoms may contribute to anemia, particularly among women and children. Riboflavin enhances iron absorption, and riboflavin deficiency decreases iron mobilization from stores. The current knowledge on riboflavin’s role in metabolic processes and its biochemical status is summarized in this review, and the available evidence on the role of riboflavin in anemia among different populations is discussed.

Niacin

Flavin adenine dinucleotide

B vitamins

Glutathione reductase

Flavin mononucleotide

10.1093/nutrit/nuac043

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Citations (18)

Suboptimal Biochemical Riboflavin Status Is Associated with Lower Hemoglobin and Higher Rates of Anemia in a Sample of Canadian and Malaysian Women of Reproductive Age

Journal of Nutrition (2019)

Abeer M. Aljaadi Ru En How Su Peng Loh Shannon E. Hunt Crystal D Karakochuk

Soluble transferrin receptor

Hemoglobin E

10.1093/jn/nxz151

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Citations (23)

A Property-Response Approach to Evaluate Acute Toxicity Profile and Pharmacological Quality of Hydro-Alcoholic Extract of Walnut Root Bark Juglans Regia Linn. in Streptozotocin-Induced Diabetic Mode

Journal of Biobased Materials and Bioenergy (2023)

Mohamed Akram Melakhessou Imene Becheker Salah Eddine Marref Mohamed Sabri Bensaad Amal Alyamani

Juglans regia L. , commonly known as walnut, is a valuable medicinal herb with the potency to treat various conditions and illnesses including diabetes, rheumatism, fever and skin illnesses. This study assessed the acute toxicity, anti-diabetic and anti-atherogenic activities of the hydro-alcoholic extract of the walnut root bark of Juglans regia L. ( Juglandaceae ), in vivo , using Wistar rats. The toxicological effects of the hydro-alcoholic extract of walnut bark Juglans regia L: are still elusive. In order to evaluate the toxicity profile of this plant, rats were orally treated with a single concentration of 2000 mg/kg and observed during a period of two weeks. For the anti-diabetic study, thirty male wistar rats (130–170 g) were randomized into 5 groups ( n = 6/group). Groups I and II served as negative and normal controls, respectively. Diabetes was induced in test groups (II–V) using 200 mg/kg of body weight (BW) streptozotocin. Concerning the clincial outcomes, no mortality, morbidity, or abnormal hematological, biochemical and histopathological alterations were observed. Accordingly, J. regia L is considered a non-toxic plant. The extract was found to limit weight loss and reduce blood glucose levels by −32.30% after 14 days of treatment for the anti-diabetic and anti-atherogenic study. The extract also reduced dyslipidaemia. Our data indicated that J. regia L contains bio-compounds that may alleviate chronic hyperglycemia while preventing cardiovascular complications by improving dyslipidaemia. This could be a potential herb for future studies to develop more effective drugs for improving glycemic and cholesterol control.

10.1166/jbmb.2023.2288

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