Jorge D. Machicado

University of Michigan–Ann Arbor

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Richard S. Kwon

University of Michigan–Ann Arbor

Allison R. Schulman

University of Michigan–Ann Arbor

Erik‐Jan Wamsteker

University of Michigan–Ann Arbor

Eileen S. Carpenter

University of Michigan–Ann Arbor

Vaibhav Sahai

University of Michigan–Ann Arbor

Jiaqi Shi

Peking University

Ahmed M. Elhossiny

University of Michigan–Ann Arbor

Nicole Peterson

University of Michigan–Ann Arbor

Padma Kadiyala

University of Michigan–Ann Arbor

Marina Pasca di Magliano

University of Michigan–Ann Arbor

Cooperative Institutions

University of Michigan–Ann Arbor

University of Pittsburgh Medical Center

University of Pittsburgh

RELX Group (Netherlands)

The University of Texas Health Science Center at Houston

The Ohio State University Wexner Medical Center

The Ohio State University

Mayo Clinic in Florida

Johns Hopkins University

Michigan Medicine

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Su1343 Increased Intestinal Tissue IgG4+ Plasma Cells in Patients With Crohn's Disease: A Novel Biomarker of Aggressive Disease Activity Following First Surgical Resection

Gastroenterology (2015)

Jorge D. Machicado Douglas J. Hartman Toufic Kabbani Claudia Ramos Rivers Miguel Regueiro

Risk Stratification

10.1016/s0016-5085(15)31614-0

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Citations (1)

Will Abandoning Fine-Needle Aspiration Increase Diagnostic Yield From Tissues Collected During Endoscopic Ultrasound?

Clinical Gastroenterology and Hepatology (2018)

Jorge D. Machicado Nirav Thosani Sachin Wani

Endoscopic Ultrasound

Cytopathology

10.1016/j.cgh.2018.04.021

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Citations (10)

The Role of Magnetic Resonance Imaging (MRI) in the Diagnosis of Pancreatic Cystic Lesions (PCLs)

Diagnostics (2023)

Elit Quingalahua Mahmoud M. Al-Hawary Jorge D. Machicado

Pancreatic cystic lesions (PCLs) are a common incidental finding on cross-sectional imaging. Given the high signal to noise and contrast resolution, multi-parametric capability and lack of ionizing radiation, magnetic resonance imaging (MRI) has become the non-invasive method of choice to predict cyst type, risk stratify the presence of neoplasia, and monitor changes during surveillance. In many patients with PCLs, the combination of MRI and the patient’s history and demographics will suffice to stratify lesions and guide treatment decisions. In other patients, especially those with worrisome or high-risk features, a multimodal diagnostic approach that includes endoscopic ultrasound (EUS) with fluid analysis, digital pathomics, and/or molecular analysis is often necessary to decide on management options. The application of radiomics and artificial intelligence in MRI may improve the ability to non-invasively stratify PCLs and better guide treatment decisions. This review will summarize the evidence on the evolution of MRI for PCLs, the prevalence of PCLs using MRI, and the MRI features to diagnose specific PCL types and early malignancy. We will also describe topics such as the utility of gadolinium and secretin in MRIs of PCLs, the limitations of MRI for PCLs, and future directions.

Magnetic resonance cholangiopancreatography

10.3390/diagnostics13040585

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Citations (2)

Gastrointestinal Bleeding Caused by Pancreatic Arteriovenous Malformation

Clinical Gastroenterology and Hepatology (2014)

Tanima Jana Jorge D. Machicado Sushovan Guha

Arteriovenous malformation

Gastrointestinal bleeding

Venous malformation

10.1016/j.cgh.2014.02.009

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Citations (2)

Supplementary Table 4 from KRT17high/CXCL8+ Tumor Cells Display Both Classical and Basal Features and Regulate Myeloid Infiltration in the Pancreatic Cancer Microenvironment

Eileen S. Carpenter Padma Kadiyala Ahmed M. Elhossiny Samantha B. Kemp Jay Li

TCGA Timer 2.0 Analysis

Basal (medicine)

Infiltration (HVAC)

10.1158/1078-0432.25956386.v1

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Supplementary Fig 12 from KRT17high/CXCL8+ Tumor Cells Display Both Classical and Basal Features and Regulate Myeloid Infiltration in the Pancreatic Cancer Microenvironment

Eileen S. Carpenter Padma Kadiyala Ahmed M. Elhossiny Samantha B. Kemp Jay Li

CXCL8 levels in patient plasma correlate with abundance of KRT17high; CXCL8+ cancer cells in neoadjuvant-treated patients.

Infiltration (HVAC)

Basal (medicine)

10.1158/1078-0432.25956431

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Supplementary Fig 7 from KRT17high/CXCL8+ Tumor Cells Display Both Classical and Basal Features and Regulate Myeloid Infiltration in the Pancreatic Cancer Microenvironment

Eileen S. Carpenter Padma Kadiyala Ahmed M. Elhossiny Samantha B. Kemp Jay Li

Organoids recapitulate the heterogeneity of human disease and retain unique tumor cell populations characterized by expression of KRT17, CXCL8 and CXCL1.

Infiltration (HVAC)

Basal (medicine)

10.1158/1078-0432.25956407.v1

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Supplementary Fig 6 from KRT17high/CXCL8+ Tumor Cells Display Both Classical and Basal Features and Regulate Myeloid Infiltration in the Pancreatic Cancer Microenvironment

Eileen S. Carpenter Padma Kadiyala Ahmed M. Elhossiny Samantha B. Kemp Jay Li

CXCL8 is expressed in a unique subpopulation of tumor epithelial cells and in tumor infiltrating granulocytes.

Basal (medicine)

Infiltration (HVAC)

10.1158/1078-0432.25956410.v1

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