Supplementary Fig 7 from KRT17<sup>high</sup>/CXCL8<sup>+</sup> Tumor Cells Display Both Classical and Basal Features and Regulate Myeloid Infiltration in the Pancreatic Cancer Microenvironment
Eileen S. CarpenterPadma KadiyalaAhmed M. ElhossinySamantha B. KempJay LiNina G. SteeleRémy NicolleZeribe C. NwosuJulia FreemanHenry DaiDaniel PagliaWenting DuKatelyn L. DonahueJacqueline MoralesPaola I. Medina-CabreraMonica E. BonillaLindsey HarrisStephanie TheValerie GunchickNicole PetersonKristee BrownMichael MatteaCarlos E. EspinozaJake McGueSarah M. KabalaRachel K. BaliiraNur M. RenolletAyden G. MooneyJianhua LiuSean BhallaJeremy P. FaridaChristopher KoJorge D. MachicadoRichard S. KwonErik‐Jan WamstekerAllison R. SchulmanMichelle A. AndersonRyan LawAnoop PrabhuPierre A. CoulombeArvind RaoTimothy L. FrankelFilip BednarJiaqi ShiVaibhav SahaiMarina Pasca di Magliano
0
Citation
0
Reference
10
Related Paper
Abstract:
<p>Organoids recapitulate the heterogeneity of human disease and retain unique tumor cell populations characterized by expression of KRT17, CXCL8 and CXCL1.</p>Keywords:
Infiltration (HVAC)
Basal (medicine)
Rosette (schizont appearance)
Fc receptor
Rosette formation
Cell surface receptor
Myeloid leukaemia
Cite
Citations (3)
This chapter describes the myeloid cells of the peripheral blood: neutrophils, eosinophils, basophils, and monocytes. It describes their basic physiology and important disease states associated with defects of each of these entities. Each of these cells arise from a common bone marrow myeloid progenitor to differentiate into their unique types.
Myelopoiesis
Cite
Citations (0)
The tumor microenvironment (TME) of diverse cancer types is often characterized by high levels of infiltrating myeloid cells including monocytes, macrophages, dendritic cells, and granulocytes. These cells perform a variety of functions in the TME, varying from of immune suppressive to immune stimulatory roles. In this review, we summarize the different myeloid cell populations in the TME and the intratumoral myeloid targeting approaches that are being clinically investigated, and discuss strategies that identify new myeloid subpopulations within the TME. The TME therapies include agents that modulate the functional activities of myeloid populations, that impact recruitment and survival of myeloid subpopulations, and that functionally reprogram or activate myeloid populations. We discuss the benefits, limitations and potential side effects of these therapeutic approaches.
Cite
Citations (107)
Abstract Aging, and age-related physiological changes, have been heavily implicated in declining immune functions. Many of these changes to the immune system include changes to the myeloid subsets, which have been poorly studied so far. Myeloid cells play crucial roles in acute infection and are involved in antigen presentation to cells of the adaptive immune system. Consequently, deciphering these age-related mechanisms holds great potential for targeting age-related changes in immunity. Here, we developed a model to map age related phenotypic changes in the myeloid compartment in all immunologically relevant murine organs. Using mass cytometry analysis (CyTOF), we assessed over 35 cell surface parameters on myeloid cells using a geriatric healthy mouse model. Results indicates age-related changes affecting the frequency and cell surface density of lineage markers on myeloid cells. Concretely, we see significant changes to cellular frequencies and marker expression within various resident myeloid populations, and exemplar organs will be presented here. Such age-related patterns may contribute to the impaired immune decline observed in aging. We are currently continually expanding this study and will validate the implications of these findings using spectral flow cytometry analysis.
Mass cytometry
Immunosenescence
Compartment (ship)
Cite
Citations (0)
CD47
Cite
Citations (407)
Recent evidence suggests that myeloid cells are critical in cancer development and therapy resistance processes. Pharmacological targeting of tumor-associated myeloid cells is an emerging approach among upcoming immune therapies. Surprisingly, myeloid cells are heterogeneous, including a subset of the myeloid cell displaying angiogenic properties in solid tumors. There is an urgent need to delineate angiogenic myeloid cell populations in order to facilitate specific targeting of protumor myeloid cells among heterogeneous pool. This review article is intended to compile all the relevant information in the literature for improved understanding of angiogenic myeloid cells and their role in tumor refractoriness to cancer therapy.
Cite
Citations (13)
Cite
Citations (24)
Cite
Citations (306)
Cite
Citations (156)
Abstract Myeloid cells are key contributors to tissue, immune and metabolic homeostasis and their alteration fuels inflammation and associated disorders such as atherosclerosis. Conversely, in a classical chicken-and-egg situation, systemic and local metabolism, together with receptor-mediated activation, regulate intracellular metabolism and reprogram myeloid cell functions. Those regulatory loops are notable during the development of atherosclerotic lesions. Therefore, understanding the intricate metabolic mechanisms regulating myeloid cell biology could lead to innovative approaches to prevent and treat cardiovascular diseases. In this review, we will attempt to summarize the different metabolic factors regulating myeloid cell homeostasis and contribution to atherosclerosis, the most frequent cardiovascular disease.
Foam cell
Cell metabolism
Homeostasis
Cite
Citations (1)