Su1343 Increased Intestinal Tissue IgG4+ Plasma Cells in Patients With Crohn's Disease: A Novel Biomarker of Aggressive Disease Activity Following First Surgical Resection
Jorge D. MachicadoDouglas J. HartmanToufic KabbaniClaudia Ramos RiversMiguel RegueiroJana G. HashashJason M. SwogerLeonard BaidooMarc SchwartzArthur BarrieMichael A. DunnDavid G. Binion
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Objective To investigate the occasion of surgical treatment of ulcerative colitis.Methods The clinical treatment and bio-chemical datas from 52 cases of ulcerative colitis were reviewed.The clinical treatment of ulcerative colitis in different stages were analysised.Results 52 cases of ulcerative colitis were transferred from medical department to surgical deparrnent.32 cases were treated with colectomy,20 cases were treated with conservativ way,among wliom 9 cases relapsed after remission,4 cases were treated by surgery.Conclusion The patients of ulcerative colitis with marked higher initial data of mucoid but lower alfxunin and ferrohemoglobin in blood serum,and those for wliom conservative treatment was inefficacy showld be Treated the Operation as soon as possible.
Medical treatment
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Fifteen patients with ulcerative colitis and 11 patients with ulcerative proctitis have been observed and studied for periods ranging from one to 15 years. It is suggested that the clinical course of the two disorders is quite distinct. Further, while the serum immunoglobulins were within normal limits in ulcerative proctitis, significant increases in the serum alpha(2)-, beta-, and gamma-globulins and in the IgA and IgG concentrations were found in ulcerative colitis. Despite total colectomy for ulcerative colitis, the serum IgG and IgA concentration remained high and even after subsequent rectal resection the relative IgA concentration continued to increase. The significance of these findings is discussed.
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IM To study the action and significance of serum tumor necrosis factorα (TNFα) and interleukin8 (IL8) in patients with ulcerative colitis. METHODS Serum TNFα (2622ng/L±20ng/L vs 1462ng/L±25ng/L, P005) and IL8 (1118ng/L±26ng/L vs 575ng/L±40ng/L, P005) in 33 patients with active ulcerative colitis and in 40 normal subjects were detected using a Sandwich ELISA. RESULTS Serum TNFα and IL8 levels in patients with ulcerative colitis were elevated significantly and related to the severity of the disease and area of lesions (P005).CONCLUSION Immune dysfunction exists in patients with ulcerative colitis. The increased serum TNFα and IL8 are related to the development of ulcerative colitis and may serve as an indicator of ulcerative colitis.
Interleukin 8
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Many studies have been conducted for the role of Ahara (~dietary habits), Vihara (~abnormal Physical activity) and Manas (~Psychological factors) and their association with pathogenesis of Ulcerative colitis, which is a subtype of inflammatory bowel disease, which pursue a protracted relapsing and remitting course, usually extending over years. The causes of relapsing of ulcerative colitis are not known. Dietary factors have been associated in the pathogenesis of ulcerative colitis as well as associated with an increased risk of relapse of ulcerative colitis. Here, we have reviewed the probable mechanisms of the role of diet and its association with pathogenesis of Ulcerative colitis (UC). In Ayurveda, on the basis of signs and symptoms ulcerative colitis can be best compared with Raktatisara. This article is an attempt to do critical review and put a light on the role of diet, faulty lifestyle and Psychological factors in occurrence and progression of Ulcerative colitis (UC), and try to explain Etiopathogenesis of Raktatisara in relation to ulcerative colitis by going through Ayurvedic texts, Google Scholar, PubMed journals etc.
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Objective To observe the levels of plasma P-selection(P-sel) and in patients with ulcerative colitis and to study the clinical significance of them. Methods the concentrations of P-sel in 18 patients with active ulcerative colitis and 13 relief ulcerative colitis were determined with ELISA method. Results The results shown that the levels of P-sel in active ulcerative colitis patients were markedly elevated and were correlated with the severity of the disease. But the levels of P-sel in relief ulcerative colitis patients have no difference with normal controls. Conclusion It is suggested that the occurrence and development of ulcerative colitis may be related to the increase of plasma P-sel. Measurement of levels of plasma P-sel and might therefore provide a tool for monitoring the clinical course and for gaiding the treatment of ulcerative colitis.
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Objective To investigate action and significance of serum nitric oxide(NO) in patients with ulcerative colitis.Methods Levels of serum NO in active stage of 33 patients with ulcerative colitis and 40 healthy controls were detected.Results Levels of serum NO in patients with ulcerative colitis were significantly high and related to severe degrees of the disease (P0.05).Conclusion Immune dysfunction exists in patients with ulcerative colitis, There are relationship between higher levels of serum NO and ulcerative colitis pathogenesis and elevation of serum NO level may be as an indicator of ulcerative colitis.
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Objective:To investigate the action of TNF-a,IL-6 and sIL-2R in the mechanism of ulcerative colitis.Methods:Bi-antibody radioimmune methods and ELISA methods were used to analysis the samples in TNF-a,IL-6 and sIL-2R of 25 cases with active ulcerative colitis.30 normal persons were assigned as the contrast group.The data of cytokines(TNF-a,IL-6,sIL-2R)among contrast group,the active and catabolic phases of ulcerative colitis were compared.That in catabolic phases of ulcerative colitis was also compared with that in contrast group,the difference were compared among slight,moderate and severe groups,The relativity among the serum level in TNF-a,IL-6 of active ulcerative colitis had been observed.Results:The level of serum TNF-a,IL-6 and sIL-2R in active ulcerative colitis was much more higher than catabolic ulcerative colitis and contrast group(P0.05).The level had no significant difference between catabolic ulcerative colitis and contrast group(P0.005).The level in severe group is higher than that in moderate and slight group(P0.05).Serum cytokines,TNF-a and IL-6 are positively related to active ulcerative colitis.(r=0.8476,P0.05).Conclusion:There is a severe disorders of cellular immunity in the patients with active ulcerative colitis.TNF-a,IL-6,sIL-2R etc play the very important roles in the genesis and development of ulcerative colitis.The serum level of the above cytokines not only reflected the development of ulcerative colitis but also could be used as biological index of the effect and estimate the prognosis.
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Ulcerative colitis is a chronic inflammatory disease affecting the colon, and its incidence is rising worldwide. The pathogenesis is multifactorial, involving genetic predisposition, epithelial barrier defects, deregulated immune responses, and environmental factors. Patients with ulcerative colitis have mucosal inflammation starting in the rectum that can extend continuously to proximal segments of the colon. Ulcerative colitis usually present with bloody diarrhoea and is diagnosed by colonoscopy and histological findings. Treatment for ulcerative colitis include 5-aminosalicylic acid drugs, steroids, and immune-suppressant. The therapeutic armamentarium for ulcerative colitis is expanding. A total of 60 respondents were interviewed and were investigated for ulcerative colitis. A predesigned and pretested was used to collect the information about the participants. For the research survey method was used for the collection of data. Results shows that mostly 70 (%) respondents were aware of ulcerative colitis and 30 (%) respondents were not aware of ulcerative colitis. In conclusion that studies ulcerative colitis.
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This paper discusses the treatment of ulcerative colitis with Traditional Chinese Medicine, and expounds the specific pathogenesis of ulcerative colitis. In addition, we put forward the application of some new technologies and methods for the scientific research on the treatment of ulcerative colitis, and summarizes the research hotspots of ulcerative colitis, hoping to provide reference for other scholars to study ulcerative colitis. Keywords: Chinese traditional; ulcerative colitis; techniques and methods; medicine treatment.
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Objective To observe the severity correlation of TNF-α、IL-6 and IL-8 levels in plasma in patients with ulcerative colitis and investigate mechanism of ulcerative colitis.Methods TNF-α,IL-6 and IL-8 levels in plasma were measured with ELISA methods in 56 patients with ulcerative colitis and 20 normal persons as a control group.The active and catabolic phases of ulcerative colitis were compared and the difference were compared among slight,moderate and sever groups.Results The level of serum TNF-α,IL-6 and IL-8 in active ulcerative colitis was much more higher than catabolic ulcerative colitis and contrast group(P0.05).The level had no significant differences between catabolic ulcerative colitis and contrast group(P0.05).The level in severe group was higher than that in moderate and slight group(P0.05).Conclusions There is a sever disorders of cellular immunity in the patients with active ulcerative colitis.TNF-α,IL-6 and IL-8 play the very important roles in the genesis and development of ulcerative colitis.The measurement of TNF-α,IL-6 and IL-8 levels in plasma may contribute to predict the severity of ulcerative colitis.
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