Jie Zhang

Anhui University

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Lianke Wang

Zhengzhou University

Xiaojiao Zhu

Anhui University

Hongping Zhou

Anhui University

Hongping Zhou

Anhui University

Yingcui Bu

Anhui Agricultural University

Zuowei Xie

Shanghai Institute of Organic Chemistry

Zhipeng Yu

Anhui University

Junjun Wang

Changji University

Yupeng Tian

Anhui University

Zhipeng Yu

Hunan Normal University

Cooperative Institutions

Pontifical Catholic University of Rio de Janeiro

310

Universidade Estadual de Londrina

306

A. Alikhanyan National Laboratory

303

Université Libre de Bruxelles

258

Beijing Normal University

256

Chinese Academy of Sciences

212

Federico Santa María Technical University

209

Institute of High Energy Physics

195

China Academy of Space Technology

162

China Institute of Atomic Energy

157

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Intrareticular Exciton Effects Regulate Photocatalytic Activity in Donor–Acceptor Olefin‐Linked Covalent Organic Frameworks

Small (2024)

Jie Zhang Wenwen Zhou Jianfeng Zhao Liangliang Xu Xue‐Kai Jiang

Abstract Olefin‐linked covalent organic frameworks (OL‐COFs) show great promise for visible‐light‐driven photocatalysis. Manipulating atomic‐level donor–acceptor interactions in OL‐COFs is key to understanding their exciton effects in this system. Here, three OL‐COFs are presented with orthorhombic lattice structures, synthesized via Knoevenagel polycondensation reaction of terephthalaldehyde and tetratopic monomers featuring phenyl, benzo[c][1,2,5]oxadiazole, and benzo[c][1,2,5]thiadiazole moieties. These OL‐COFs feature tunable donor–acceptor interactions, making them ideal for studying exciton effects in olefin‐linked systems. Comprehensive analyses, including temperature‐dependent photoluminescence spectra, ultrafast spectroscopy, and theoretical calculations, reveal that stronger donor–acceptor interactions lead to reduced exciton binding energy ( E b ), accelerated exciton dissociation, and longer‐lived photogenerated charges, thereby enhancing photocatalytic performance. Notably, The TMO‐BDA COF, with the lowest E b , demonstrates superior photocatalytic activity in one‐pot sequential organic transformation and excellent catalytic performance in gram‐scale reactions, highlighting its potential for practical applications. This work provides valuable insights into regulating the exciton effect at the molecular level in OL‐COFs, offering pathways to enhance photocatalytic efficiency.

Acceptor

10.1002/smll.202408324

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Citations (1)

CCDC 2172263: Experimental Crystal Structure Determination

The Cambridge Structural Database (2022)

Shimeng Li Jie Zhang Zuowei Xie

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

10.5517/ccdc.csd.cc2bxf0q

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Solvatochromic Two-Photon Fluorescent Probe Enables In Situ Lipid Droplet Multidynamics Tracking for Nonalcoholic Fatty Liver and Inflammation Diagnoses

Analytical Chemistry (2022)

Houshi Huang Yingcui Bu Zhipeng Yu Mengtao Rong Rui Li

Intracellular lipid storage and regulation occur in lipid droplets, which are of great significance to the physiological activities of cells. Herein, a lipid droplet-specific fluorescence probe (lip-YB) with a high quantum yield (QYlip-YB = 73.28%), excellent photostability, and quickly polarity sensitivity was constructed successfully. Interestingly, lip-YB exhibited remarkable two-photon (TP) characteristics, which first realized real-time monitoring of the lipid droplet multidynamics process, diagnosing nonalcoholic fatty liver disease (NAFLD) and inflammation in living mice via TP fluorescence imaging. It is found that the as-prepared lip-YB provides a new avenue to design lipid droplet-specific imaging probes, clarifies its roles and mechanisms in cell metabolism, and can timely intervene in lipid droplet-related diseases during various physiological and pathological processes.

Lipid droplet

Fluorescence-lifetime imaging microscopy

Liver X receptor

10.1021/acs.analchem.2c01960

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Self-Monitoring the Endo-Lysosomal Escape and Near-Infrared-Activated Mitophagy To Guide Synergistic Type-I Photodynamic and Photothermal Therapy

Analytical Chemistry (2021)

Yingcui Bu Xiaojiao Zhu Haoran Wang Jie Zhang Lianke Wang

Considering the multiple biological barriers before the entry of photosensitizers (PSs) into cytoplasm, it is of paramount importance to track PSs to elucidate their behaviors and distributions to guide the photodynamic therapy (PDT). Also, the developed PSs suffer from strong oxygen dependency. However, reports on such ideal theranostic platforms are rare. Herein, we developed a theranostic platform (CMTP-2) based on the coumarin-based D-π-A system, which, for the first time, can reveal the holistic intracellular delivery pathway and near-infrared (NIR)-activated mitophagy to guide synergistic type-I PDT and photothermal therapy. The dynamic endo-lysosomal escape of CMTP-2 was monitored, as well as its changeable distributions in endosomes, lysosomes, and mitochondria, demonstrating the preferential accumulation in mitochondria at the end. Upon NIR-I irradiation, CMTP-2 generated toxic radicals and heat, triggering the execution of mitophagy and apoptosis. In vivo experiments on mice indicated that CMTP-2 under 808 nm irradiation realized complete cancer ablation, showing great potential for advancements in synergistic phototherapy.

10.1021/acs.analchem.1c02310

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Citations (30)

Triphenylamine-perylene diimide conjugate-based organic nanoparticles for photoacoustic imaging and cancer phototherapy

Colloids and Surfaces B Biointerfaces (2021)

Haolan Li Liangliang Yue Li Li Genyan Liu Jie Zhang

Biocompatibility

Triphenylamine

Conjugate

Diimide

10.1016/j.colsurfb.2021.111841

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Citations (19)

CCDC 747079: Experimental Crystal Structure Determination

The Cambridge Structural Database (2011)

Wei Yuan Min Liu Nan Jiang Zhi Kai Guo Jing Ma

10.5517/cct2dbl

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Black Titania Janus Mesoporous Nanomotor for Enhanced Tumor Penetration and Near-Infrared Light-Triggered Photodynamic Therapy

ACS Nano (2024)

Kexin Lv Mengmeng Hou Yufang Kou Hongyue Yu Mengli Liu

Thanks to their excellent photoelectric characteristics to generate cytotoxic reactive oxygen species (ROS) under the light-activation process, TiO2 nanomaterials have shown significant potential in photodynamic therapy (PDT) for solid tumors. Nevertheless, the limited penetration depth of TiO2-based photosensitizers and excitation sources (UV/visible light) for PDT remains a formidable challenge when confronted with complex tumor microenvironments (TMEs). Here, we present a H2O2-driven black TiO2 mesoporous nanomotor with near-infrared (NIR) light absorption capability and autonomous navigation ability, which effectively enhances solid tumor penetration in NIR light-triggered PDT. The nanomotor was rationally designed and fabricated based on the Janus mesoporous nanostructure, which consists of a NIR light-responsive black TiO2 nanosphere and an enzyme-modified periodic mesoporous organosilica (PMO) nanorod that wraps around the TiO2 nanosphere. The overexpressed H2O2 can drive the nanomotor in the TME under catalysis of catalase in the PMO domain. By precisely controlling the ratio of TiO2 and PMO compartments in the Janus nanostructure, TiO2&PMO nanomotors can achieve optimal self-propulsive directionality and velocity, enhancing cellular uptake and facilitating deep tumor penetration. Additionally, by the decomposition of endogenous H2O2 within solid tumors, these nanomotors can continuously supply oxygen to enable highly efficient ROS production under the NIR photocatalysis of black TiO2, leading to intensified PDT effects and effective tumor inhibition.

Penetration (warfare)

10.1021/acsnano.4c03652

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Citations (13)

Near-infrared light activated photosensitizer with specific imaging of lipid droplets enables two-photon excited photodynamic therapy

Journal of Materials Chemistry B (2022)

Tengdie Wu Xin Lu Zhipeng Yu Xiaojiao Zhu Jie Zhang

Two-photon excited phototherapy has attracted considerable attention due to its advantages such as deeper penetration depth and higher spatial resolution. The lack of a high-performance photosensitizer with large two-photon absorption cross-sections and specific targeting ability makes the efficacy of phototherapy in the treatment of cancer unsatisfactory. Here, a new BODIPY-derived photosensitizer 6DBF2 is designed with two-photon photosensitization for two-photon excited photodynamic therapy in vivo. 6DBF2 possesses good two-photon absorption and efficient 1O2 generation upon near-infrared laser excitation. Excellent targeting specificities to lipid droplets of 6DBF2 without any encapsulation or modification at a low working concentration of 0.1 μM is in favor of efficient photodynamic therapy. In vitro cancer cell ablation and in vivo tumor ablation inside mice models upon two-photon irradiation in NIR demonstrate the outstanding therapeutic performance of 6DBF2 in two-photon excited photodynamic therapy. This work thus discusses a rare example of lipid droplets targeting two-photon excited photodynamic therapy for deep cancer tissue imaging and treatment under near-infrared light irradiation.

Two-photon excitation microscopy

10.1039/d2tb02466g

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Citations (17)

CCDC 1957716: Experimental Crystal Structure Determination

The Cambridge Structural Database (2020)

Jie Zhang Yazhou Ding

10.5517/ccdc.csd.cc23q545

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Breaking Barriers: A Gender Comparison of Newcomer Chinese High-Skilled Workers in Japanese Enterprises

XIX ISA World Congress of Sociology (July 15-21, 2018) (2018)

Jie Zhang

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