Yousra Falfoul

Tunis El Manar University

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Trends

Author Order

Document Type

Co-Authors

L. El Matri

Tunis El Manar University

A. Chebil

Faculté de médecine de Tunis

Khaled El Matri

Tunis El Manar University

A. Hassairi

Tunis El Manar University

Imen Habibi

University of Lausanne

Daniel F. Schorderet

École Polytechnique Fédérale de Lausanne

R. Bouraoui

Hopital Universitaire Hedi Chaker

Ahmed Turki

University of Ha'il

N. Chaker

Hopital Universitaire Hedi Chaker

Nibrass Chaker

Faculté de médecine de Tunis

Cooperative Institutions

Tunis El Manar University

Tunis University

Faculté de médecine de Tunis

Hopital Universitaire Hedi Chaker

Habib hospital Thameur

Hôpital Charles-Nicolle

Institute of Ophthalmology

Hôpital Razi de La Manouba

Hôpital Mongi Slim

University of Lausanne

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

Central corneal thickness in a healthy Tunisian population.

La Tunisie Médicale (2021)

A. Chebil Racem Choura Yousra Falfoul Olfa Fekih L. El Matri

AIM To study the central corneal thickness of a Tunisian population and determine the influence of age, gender, axial length and refractive error on central corneal thickness (CCT) values. METHODS An observational, cross-sectional study was conducted on 608 eyes of consecutive Tunisian patients without ophthalmic disease. Corneal tomography (Oculus Pentacam, USA) and a complete eye examination were performed on all patients. The relationship between the central corneal thickness values and variables of age, refractive error, axial length and gender was assessed. RESULTS The mean central corneal thickness was 522±37.17μm (range 461 to 655 μm). No statistical association was found between central corneal thickness values and variables of age, refractive error, axial length and gender. CONCLUSIONS The normal CCT value in the Tunisian population was of 522±37.17 µm. We have analyzed, for the first time, normal central corneal thickness values of a healthy Tunisian population.

Corneal Diseases

Source

Cite

Citations (2)

Swept source OCT-Angiography assessing a case of aneurysmal type 1 neovascularization secondary to high-myopic posterior staphyloma

European Journal of Ophthalmology (2020)

Khaled El Matri R. Bouraoui Yousra Falfoul A. Chebil L. El Matri

Aim: To report an uncommon case of aneurysmal type 1 neovascularization (polypoidal choroidal vasculopathy) secondary to high-myopic staphyloma in a Caucasian patient, assessed with multimodal imaging including swept source OCT-Angiography. Methods: Observational case report Results: About 73-year-old Caucasian male patient with high myopia (axial length = 27.24 mm). Fundus examination showed a myopic conus and a deep orange-brownish nodular lesion at the edge of a deep haemorrhage and connected to a large choroidal vessel. ICGA showed a circular hyperfluorescent lesion in mid-phase, without any branching vascular network. OCT-Angiography could detect the aneurysmal lesion non-invasively as a small circular high-flow lesion in the outer retina slab, with a shadowing in the choriocapillaris slab. At the level of the aneurysmal lesion, structural OCT showed a high bilobed PED, without any subretinal fluid. A vascular flow was noted within the PED on cross-sectional OCT-A, confirming the vascular aneurysmal nature of this lesion. Additionally, swept source OCT highlighted the presence of an abrupt change in choroidal thickness, from 62 µm in the peripapillary area to 120 µm underneath the polypoidal lesion, with dilated choroidal vessels. Conclusion: To our knowledge, this is the first report of OCT-A findings in aneurysmal (polypoidal) dilation secondary to high-myopic staphyloma. We could demonstrate the usefulness of OCT-A detecting non-invasively the aneurysmal dilation and the usefulness of swept source OCT assessing the choroidal structure to better understand the pathophysiology of this uncommon finding.

Fundus (uterus)

Choroid

10.1177/1120672120984396

Cite

Citations (1)

A novel homozygous c.1154+3_1151+6delAAGT mutation in CERKL causes autosomal recessive retinitis pigmentosa with a special phenotype in a consanguineous Tunisian Family

Acta Ophthalmologica (2016)

L. El Matri Yousra Falfoul Imen Habibi Ahmed Turki R. Maamouri

Purpose The aim of our study was to assess the clinical phenotype and to determine the causative gene in a Tunisian family with an autosomic recessive retinitis pigmentose (arRP). Methods All accessible members of a consanguineous Tunisian family were included and underwent full ophthalmic examination with best corrected Snellen visual acuity, fundus photography, optical coherence tomography (SD‐OCT) and full field electroretinography (ERG). Index patient was selected for whole exome sequencing (WES) followed by homozygosity mapping. All detected variations were confirmed by direct Sanger sequencing. Results The clinical data of the patients showed typical hallmarks of RP symptoms for which affected individuals initially experienced night blindness with progressive visual loss and hemeralopia since the first decade of life. Visual acuity at baseline ranged from 1/10 to 5/10. Funduscopy revealed essentially mild optic disc and retinal atrophy and virtually no clumped pigmentation. Macula was normal in young patients and showed atrophic alteration in advanced stages. ERG was unrecordable in scotopic conditions and the cone responses were markedly hypovolted. Homozygosity mapping and whole exome sequencing identified a 4‐pb deletion, c.1154+3_1151+6delAAGT, located in the donor splice site of intron 8 of CERKL . The mutation impacts pre‐mRNA splicing of CERKL . This new deletion was present at a homozygous state in the two affected sons and was heterozygous in the parents. It was not present in the unaffected sister. Conclusions Mutations in CERKL gene have been reported in patients with retinitis pigmentosa, c.1154+3_1151+6delAAGT is a novel splicing variant associated with arRP. Extending the mutation spectrum of CERKL with additional families is important for genotype‐phenotype correlations.

Disease gene identification

Sanger sequencing

Electroretinography

10.1111/j.1755-3768.2016.0540

Cite

Citations (0)

Subthreshold micropulse laser adjuvant to bevacizumab versus bevacizumab monotherapy in treating diabetic macular edema: one- year- follow-up

Therapeutic Advances in Ophthalmology (2021)

L. El Matri A. Chebil Khaled El Matri Yousra Falfoul Zouheir Chebbi

To compare the therapeutic impact of combining intravitreal injections of bevacizumab (IVB) with micropulse laser (MPL) in central diffuse diabetic macular edema (DME) versus IVB monotherapy during 12 months follow-up.We conducted a retrospective comparative study of 98 treatment-naive eyes (63 patients) with central diffuse DME. The first group of patients (IVB + MPL group, n = 49) was treated with 3 monthly IVB followed by MPL within 1 week after the third injection. Patients were then followed and treated on a pro re nata (PRN) basis, with MPL retreatment if necessary. The changes in best-corrected visual acuity (BCVA), central macular thickness (CMT), number of IVB injections and MPL sessions were evaluated at 4, 8, and 12 months. A control group of diabetic patients with treatment-naive DME was treated with standard protocol of 3 monthly IVB as monotherapy then followed on a PRN basis (IVB group, n = 49). Statistic comparaison of BCVA, CMT, and IVB number variation was interpreted at 12 months between both groups.In IVB + MPL group, baseline BCVA improvement was not significant at 4 and 8 months (p = 0.90, p = 0.08), and was statistically significant (p = 0.01) at 12 months. Mean CMT significantly decreased at 4, 8, and 12 months (p < 0.01) in IVB + MPL group. The difference in BCVA (p = 0.091) and CMT (p = 0.082) variation at 12 months between both groups was not significant but the number of injections was significantly lower in IVB + MPL group (4.1 ± 1.5 injections) compared to IVB group (7.2 ± 1.3 injections) (p < 0.005).Combining intravitreal injections of bevacizumab and MPL in the treatment of DME is effective and safe. This protocol may decrease the number of IVB and its frequency. It offers the advantage of lasting therapeutic response with fewer recurrences.

Diabetic macular edema

Pro re nata

10.1177/25158414211040887

Cite

Citations (14)

Homozygous mutation in ABCA4 associated with cone rod dystrophy in a patient with Turner syndrome.

La Tunisie Médicale (2021)

Yousra Falfoul Imen Habibi Ahmed Turki Achraf Ben Yakhlef Khaled El Matri

Purpose We report a special case of a patient who presented with two rare genetic diseases, Turner syndrome and cone-rod dystrophy (CRD), caused by mutation in the ABCA4 gene. Methods We present a case of a 12-year-old female with a progressive visual loss, poor night vision and short stature. We performed a clinical, karyotype of peripheral blood and molecular genetic study. DNA sample from the index patient was subjected to whole exome sequencing. Variants localized in homozygous regions were validated by Sanger sequencing. Results Fundus examination presented CRD phenotype and the general examination revealed short stature, aortic coarctation and infantile uterus, without visible ovaries on pelvic ultrasound. The karyotype of peripheral blood showed monosomy 45,X. We identified a known homozygous deletion c.[885delC];[885delC] in ABCA4, resulting in a frameshift at the position p.[L296Cfs*4];[ L296Cfs*4] . In addition, mutations in RPGR and ORF15 were excluded. Conclusions Several ocular disorders are known to be associated with Turner syndrome, however, in this case, we hypothesize that CRD is not related to Turner syndrome but may be a manifestation of the lack of a normal X chromosome with ABCA4 mutation.

Sanger sequencing

ABCA4

Fundus (uterus)

Source

Cite

Citations (0)

Subthreshold micropulse laser treating residual macular subretinal fluid after rhegmatogenous retinal detachment surgery: A case report

Indian Journal of Ophthalmology - Case Reports (2021)

Khaled El Matri Yousra Falfoul Nibrass Chaker A. Chebil R. Bouraoui

We report the effect of micropulse laser (MPL) treating a case of residual subretinal fluid (SRF) after rhegmatogenous retinal detachment (RRD) surgery. A 38-year-old male patient presenting with residual SRF 6 months following RRD surgery. Initial central macular thickness (CMT) was 243 μm. A 3 × 3 MPL macular grid was performed with moderate reduction of SRF (CMT = 191 μm). Five months following second MPL session, we noted a complete resolution of SRF (CMT = 98 μm) and fundus autofluorescence did not show any laser scare. Micropulse laser might represent a new non-invasive efficient treatment for residual SRF after RDD surgery. MPL effect seemed to be delayed and close follow-up was necessary.

Subthreshold conduction

10.4103/ijo.ijo_2728_20

Cite

Citations (0)

Correction: Habibi I. et al. “Clinical and Genetic Findings of Autosomal Recessive Bestrophinopathy (ARB)” Genes, 2019, 10, 953

Genes (2020)

Imen Habibi Yousra Falfoul Margarita G. Todorova Stefan Wyrsch Veronika Vaclavik

The authors wish to make a correction to the published version of their paper [...]

Wish

10.3390/genes11050503

Cite

Citations (2)

Polypoidal choroidal vasculopathy in a patient with angioid streaks treated by bevacizumab.

La Tunisie Médicale (2020)

A. Chebil Rahma Saidane Yousra Falfoul Khaled El Matri Racem Choura

Objective We report the association of polypoid choroidal vasculopathy (PVC) with angioid streaks (AS) secondary to pseudoxanthoma elasticum (PXE) treated by intravitreal injection of bevacizumab. Case report A 50-year-old patient, followed in dermatology for a PXE, who consulted for a consulted for a decreased vision in his right eye (RE) for a month. On examination, best corrected visual acuity (BCVA) was at 1/20 P14 in the RE and at 8/10 P2 in the left eye (LE). Fundus examination revealed AS in both eyes, large patches of exudate at the posterior pole with retinal hemorrhages in the RE. Fluorescein angiography (FA) showed constant hypofluorescence by mask effect due to exudates and macular early hyperfluorescence with late diffusion associated with small hyperfluorescent lesions in the RE. We suspected CNV type 2. Macular Spectral Domain optical coherence tomography (SD-OCT) showed significant retinal infiltration with pre-epithelial hyper-reflectivity bracing the diagnosis of type 2 CNV. In view of the importance of exudates and intra-retinal infiltration, we completed by indocyanine green angiography (ICGA) which showed hypercyanecent vascular dilations grouped in clusters of grapes relevant to an associated VPC. The patient received eight monthly intravitreal (IVT) injections of bevacizumab with good anatomical evolution. At 10 months, visual acuity was 1/10 with disappearance of exudates and retinal infiltration. Conclusion Patients with AS should receive regular follow-up given the risk of CNV but also of VPC, especially in cases of PXE. Multimodal imaging is of great help and ICGA remains inescapable.

Angioid streaks

Pseudoxanthoma Elasticum

Fundus (uterus)

Indocyanine Green

Source

Cite

Citations (0)

Corrélations phénotype–génotype de la rétinopathie pigmentaire non syndromique : à propos de dix familles tunisiennes

Journal Français d Ophtalmologie (2016)

A. Chebil Yousra Falfoul Imen Habibi Francis L. Munier Daniel F. Schorderet

RPE65

10.1016/j.jfo.2015.08.013