Yanming Han

Dankook University

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Lane Pineda

Nutreco (Netherlands)

Sandra van Kuijk

Nutreco (Netherlands)

David H. Baker

AstraZeneca (Sweden)

Yuanyuan Wu

Fudan University Shanghai Cancer Center

C.M. Parsons

University of Illinois Urbana-Champaign

Xin Gen Lei

Shanghai University of Traditional Chinese Medicine

Lv‐Hui Sun

Huazhong Agricultural University

Karolina Von Zuben Augusto

Trouw Nutrition (Brazil)

Mehdi Toghyani

Poultry CRC

Joshua Gong

Agriculture and Agri-Food Canada

Cooperative Institutions

Ministry of Agriculture and Rural Affairs

Chinese Academy of Agricultural Sciences

Huazhong Agricultural University

University of Illinois Urbana-Champaign

Universidade Estadual Paulista (Unesp)

Chinese Academy of Sciences

Dankook University

University of Guelph

Trouw Nutrition (Brazil)

Lanzhou University

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Short-chain fatty acid administration via water acidifier improves feed efficiency and modulates fecal microbiota in weaned piglets

Journal of Animal Science (2021)

Mandy M Lingbeek Klaudyna Borewicz E. Febery Yanming Han John Doelman

This study examined the effect of a water acidifier containing free- and buffered-short chain fatty acids (SCFA-WA) on growth performance and microbiota of weaned piglets. In total, 192 male piglets, approximately four weeks of age, were allocated to 24 pens (12 per treatment) with eight piglets per pen. The piglets received either regular drinking water (negative control) or drinking water with the acidifier supplied at 2 L/1000L. Body weight and feed intake were measured weekly on pen level. During the first two weeks, daily visual assessment and scoring of the faeces was conducted. Faecal samples of three piglets per pen were collected on day 14 and 42 for high-throughput sequencing analysis of the microbiota. Piglets offered SCFA-WA had significantly improved feed efficiency in the third week (P=0.025) and over the whole study period (day 0-42, P=0.042) compared to piglets in the negative control group, with a strong tendency observed during the first feeding phase (day 0-21, P=0.055). Furthermore, the water acidifier group had a higher water intake than piglets provided with control water during the second feeding phase (day 21-42, P=0.028) and over the whole study period (day 0-42, P=0.043). There was no significant difference in body weight, average daily gain, or average daily feed intake (day 0-21, 21-42, 0-42). Furthermore, there was no overall significant difference in faecal scoring between the treatments. In terms of the faecal microbiota response, piglets offered the water acidifier showed a significantly higher relative abundance (RA) of genus Clostridium sensu stricto 1 and a lower RA of genus Streptococcus compared to the control. Furthermore, the redundancy analysis (RDA) showed a positive association between improved feed efficiency and daily weight gain and RA of Butyricicoccus and Faecalibacterium. In conclusion, consumption of the water acidifier containing free- and buffered- SCFA modulated the microbiota and improved feed efficiency in piglets.

Negative control

10.1093/jas/skab307

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Citations (17)

Efficacy of a Synergistic Blend of Organic Acids and ß-1,4 Mannobiose on Cecal Salmonella Counts and Growth Performance in Salmonella Challenged Broiler Chickens: A Meta-Analysis

Animals (2021)

Sandra van Kuijk Yanming Han

This study aimed at investigating the effect of a functional synergistic feed additive blend, containing organic acids and ß-1,4 mannobiose, on cecal Salmonella counts and growth performance of broiler chickens. A meta-analysis combining 13 individual studies, executed in Salmonella-challenged broilers comparing a control diet with and without the synergistic blend, was performed. Cecal Salmonella colonies and overall growth performance were measured. Raw data from all studies were combined and analyzed using PROC MIXED in SAS, taking the within and between-study variation into account. In the first 14 days post-inoculation (DPI), cecal Salmonella was reduced by 0.429 log CFU/g (p = 0.011, n = 10 comparisons from five studies) when feeding the synergistic blend compared to the control group. During 15-34 DPI, the overall means were not different between treatments (0.069 log CFU/g; p = 0.519, n = 12 comparisons from eight studies). The feed conversion ratio was improved when feeding the synergistic blend compared to the control diet (1.474 vs. 1.482, respectively; p = 0.002). In conclusion, feeding a synergistic blend, containing organic acids and ß-1,4 mannobiose amongst other ingredients, reduced cecal Salmonella counts during the first 14 DPI and improved growth performance of Salmonella challenged broilers compared to a control diet.

10.3390/ani11102988

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Citations (2)

Protein quality and metabolizable energy yield of pork loin are not affected by cooking

Canadian Journal of Animal Science (1995)

J.L. Emmert Audra E. Hortin Yanming Han David H. Baker

In a chick growth assay, the protein quality (PER) of pork loin was not affected by roasting, but both raw and roasted pork loin produced higher PER values than that obtained with dehulled SBM. True metabolizable energy, assessed in a precision-fed cockerel assay, was similar for raw and roasted pork loin. Key words: Protein quality, energy yield, pork loin, cooking, chicks

Loin

Roasting

10.4141/cjas95-074

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Citations (0)

Weaned piglets prefer feed with hydroxychloride trace minerals to feed with sulfate minerals

Translational Animal Science (2019)

Sandra van Kuijk Marleen Fleuren Anke P J Balemans Yanming Han

Abstract The aim of this study was to determine whether newly weaned piglets had a preference for diets containing hydroxychloride trace minerals (HTM). To test this, two preference tests were set up. In Exp. 1, the piglets could choose between HTM or inorganic, originating from sulfate trace minerals (STM) in the form of sulfates. Two treatments were applied with high Cu levels (160 ppm Cu added) or low Cu levels (15 ppm Cu added). All diets contained 110 ppm added Zn from the same source as Cu in the respective diet. The pigs could choose between a diet with hydroxychloride Cu and Zn or with Cu and Zn originating from sulfates at the same mineral levels. The piglets were included in the study from weaning until 34 d after weaning. In Exp. 2, the piglets could also choose between HTM and STM. However, automated feeding stations were used to collect individual feed intake data. Similarly two treatments were applied, one with high Cu levels (160 ppm added Cu) and one with slightly lower Cu levels (140 ppm added Cu until 28 d after weaning, thereafter 15 ppm added Cu). All diets contained 110 ppm added Zn from the same source as Cu in the respective diet. The piglets were followed until 35 d after weaning. The current studies showed that when piglets were given a choice, they preferred diets with HTM. This effect resulted only in a significant (P < 0.05) preference for HTM at high dietary Cu levels (160 ppm) ranging from 76% to 81% in the first and second week of Exp. 1 to between 53.4% and 57.8% in the overall experiment period of Exp. 2. This preference was less pronounced at levels of 140 ppm added or less. Individual feed intake and gain measurements did not show any link between the preference and the performance.

Trace Minerals

Preference test

10.1093/tas/txz035

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Citations (5)

Effect of Overprocessing on Availability of Amino Acids and Energy in Soybean Meal

Poultry Science (1992)

C.M. Parsons Katsunori Hashimoto Karen J. Wedekind Yanming Han David H. Baker

Commercial, dehulled, solvent-extracted soybean meal (DSBM) was overprocessed by autoclaving at 121 C and 105 kPa for 0, 20, 40, or 60 min. Analyzed concentrations (acid hydrolysis followed by ion-exchange chromatography) of lysine and cystine, and to a lesser extent arginine, in DSBM were reduced by increased autoclaving time. Autoclaving time had little or no effect on levels of other amino acids. Performance of chicks fed 40-min autoclaved DSBM as the sole source of dietary protein was inferior to that of chicks fed unautoclaved DSBM. True digestibilities of several amino acids in DSBM decreased (P<.05) as autoclaving time increased, with the largest decreases being observed for lysine, cystine, histidine, and aspartic acid. The effect of autoclaving on lysine was due both to reduced concentration of analyzed lysine and reduced digestibility of the lysine remaining after autoclaving. True digestibilities of most amino acids determined in conventional cockerels were higher (P<.05) than those determined in cecectomized cockerels. Bioavailabilities determined by chick growth assay of lysine in unautoclaved DSBM and DSBM autoclaved for 40 min were 82 and 70%, respectively. Autoclaving had no significant effect on TMEn of DSBM.

10.3382/ps.0710133

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Citations (165)

Adding wheat middlings, microbial phytase, and citric acid to corn-soybean meal diets for growing pigs may replace inorganic phosphorus supplementation.

Journal of Animal Science (1998)

Yanming Han Karl R. Roneker W. G. Pond Xin Gen Lei

Three experiments were conducted with 96 growing Landrace x Yorkshire x Duroc crossbreds to determine the collective effectiveness of cereal phytase from wheat middlings, microbial phytase, and citric acid in improving phytate-P bioavailability in corn-soy diets. In Exp. 1, 40 gilts (7 wk old) were fed five diets for 8 wk. Diets 1, 2, and 3 were low-P, corn-soybean meal diets (CSB) + 0, .1, or .2% inorganic P (Pi) as calcium phosphate, respectively. Diet 4 was a similar corn-soy diet that included 15% wheat middlings (461 cereal phytase U/kg). Diet 5 was the CSB + microbial phytase (1,200 U/kg; Natuphos, BASF, Mount Olive, NJ). In Exp. 2, 16 barrows (8 wk old) were fed two diets for 6 wk. Diet 1 was the same as Diet 3 of Exp. 1 (.2% Pi). Diet 2 was Diet 4 of Exp. 1 + microbial phytase (300 U/kg). In Exp. 3, 40 barrows and gilts (6 wk old) were fed four diets for 6 wk. Diets 1 and 2 were the same as those in Exp. 2. Diet 3 was Diet 2 of Exp. 2 + 1.5% citric acid. Diet 4 was similar to Diet 3 but contained 10 instead of 15% wheat middlings. In Exp. 1, pigs fed the low-P, CSB (Diet 1) had lower (P < .05) ADG, ADFI, plasma Pi concentration, bone strength, and mobility score than pigs of the other four treatments. Measurements for pigs fed the 15% wheat middlings diet were not significantly different from those of pigs fed the CSB + .1% Pi or microbial phytase. In Exp. 2, ADG (P=.06) during wk 1 to 3 and gain:feed ratio (P < .02) and plasma Pi concentration (P < .005) during all weeks favored pigs fed the CSB + .2% Pi compared with the other diet including 15% wheat middlings. In Exp. 3, identical ADG during all weeks and similar plasma Pi concentrations at wk 4 and 6 were observed between pigs fed the two citric acid diets (Diets 3 and 4) and the CSB + .2% Pi (Diet 1). Pigs fed Diet 4 (10% wheat middlings) had even higher (P < .02) gain:feed ratio during wk 1 to 3 than those fed Diet 1. It seems feasible to completely replace calcium phosphate with 10 to 15% wheat middlings, 300 U microbial phytase/ kg, and 1.5% citric acid in the corn-soy diets for growing pigs.

Phytase

10.2527/1998.76102649x

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Citations (54)

Nutritional Evaluation of Soybeans Varying in Trypsin Inhibitor Content

Poultry Science (1991)

Yanming Han C.M. Parsons T. Hymowitz

A series of experiments was conducted to assess, by various methods, the nutritional value of a raw, Kunitz inhibitor-free, low trypsin-inhibitor soybean variant (LTS) in comparison with raw conventional soybeans (RCS) and heated dehulled soybean meal (HDS). The gross energy, protein, and amino acid concentrations of LTS were similar to those of RCS. The protein quality of the soybeans was compared in two trials in which young chicks were fed 9% or 16% CP diets containing one of the soybeans as the sole source of dietary protein. The protein quality of LTS was superior to that of RCS but inferior to that of HDS. True digestibilities of amino acids and TMEn were determined with a precision-fed cockerel assay using conventional and cecectomized birds. No significant effect of bird type on digestibility was found. The mean digestibility of 16 amino acids in RCS, LTS, and HDS was found to be approximately 68, 83, and 92%, respectively. The TMEn of LTS was greater than that of RCS. Chick growth assays indicated that amino acid bioavailability values of lysine and TSAA for LTS were greater than those for RCS but slightly lower than those for HDS. In an additional chick assay with a corn and HDS diet (22% CP), the dietary HDS protein was replaced with LTS or RCS protein at 25, 50, 75, or 100%. Performance of chicks fed LTS was better than that of chicks fed RCS at all replacement levels, but the difference was not significant at the 25% replacement level. Feed efficiencies of chicks fed 25 or 50% of the dietary soybean protein as LTS were not significantly different from that of chicks fed the corn and HDS control diet. The results of the present study indicated that the nutritive value of LTS is substantially greater than that of RCS but somewhat lower than that of HDS.

Trypsin inhibitor

Protein quality

Biological value

10.3382/ps.0700896

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Citations (50)

Overexpression of Cellular Glutathione Peroxidase Does Not Affect Expression of Plasma Glutathione Peroxidase or Phospholipid Hydroperoxide Glutathione Peroxidase in Mice Offered Diets Adequate or Deficient in Selenium

Journal of Nutrition (1997)

Wen‐Hsing Cheng Ye‐Shih Ho D.A. Ross Yanming Han Gerald F. Combs

Phospholipid-hydroperoxide glutathione peroxidase

GPX3

GPX6

GPX4

GPX1

Affect

Glutathione reductase

10.1093/jn/127.5.675

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Citations (87)

An integrated mycotoxin-mitigating agent can effectively mitigate the combined toxicity of AFB1, DON and OTA on the production performance, liver and oviduct health in broiler breeder hens

Food and Chemical Toxicology (2023)

Meng-Ling Ruan Jie Wang Zhiyuan Xia Xuewu Li Bo Zhang

Oviduct

Dose

10.1016/j.fct.2023.114159

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Citations (3)

Dietary organic acids ameliorate high stocking density stress-induced intestinal inflammation through the restoration of intestinal microbiota in broilers

Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology (2022)

Dong Dai Guanghai Qi Jing Wang Haijun Zhang Kai Qiu

High stocking density (HSD) stress has detrimental effects on growth performance, intestinal barrier function, and intestinal microbiota in intensive animal production. Organic acids (OA) are widely used as feed additives for their ability to improve growth performance and intestinal health in poultry. However, whether dietary OA can ameliorate HSD stress-induced impaired intestinal barrier in broilers remains elusive. In this study, a total of 528 one-day-old male Arbor Acres broilers were randomly allocated into 3 treatments with 12 replicates per treatment including 10 birds for normal stocking density and 17 birds for HSD. The dietary treatments were as follows: 1) Normal stocking density + basal diet; 2) HSD + basal diets; 3) HSD + OA.HSD stress can induce increased levels of serum corticosterone, lipopolysaccharides, interleukin-1β, tumor necrosis factor-α, and down-regulated mRNA expression of ZO-1, resulting in compromised growth performance of broilers (P < 0.05). Dietary OA could significantly reduce levels of serum corticosterone, lipopolysaccharides, interleukin-1β, and tumor necrosis factor-α, which were accompanied by up-regulated interleukin-10, mRNA expression of ZO-1, and growth performance (P < 0.05). Moreover, OA could down-regulate the mRNA expression of TLR4 and MyD88 to inhibit the NF-κB signaling pathway (P < 0.05). Additionally, HSD stress significantly decreased the abundance of Bacteroidetes and disturbed the balance of microbial ecosystems, whereas OA significantly increased the abundance of Bacteroidetes and restored the disordered gut microbiota by reducing competitive and exploitative interactions in microbial communities (P < 0.05). Meanwhile, OA significantly increased the content of acetic and butyric acids, which showed significant correlations with intestinal inflammation indicators (P < 0.05).Dietary OA ameliorated intestinal inflammation and growth performance of broilers through restoring the disordered gut microbial compositions and interactions induced by HSD and elevating short-chain fatty acid production to inhibit the TLR4/NF-κB signaling pathway. These findings demonstrated the critical role of intestinal microbiota in mediating the HSD-induced inflammatory responses, contributing to exploring nutritional strategies to alleviate HSD-induced stress in animals.

Basal (medicine)

Proinflammatory cytokine

Occludin

Corticosterone

10.1186/s40104-022-00776-2

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Citations (27)