Yanming Han

Dankook University

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Lane Pineda

Nutreco (Netherlands)

Sandra van Kuijk

Nutreco (Netherlands)

David H. Baker

AstraZeneca (Sweden)

Yuanyuan Wu

Fudan University Shanghai Cancer Center

C.M. Parsons

University of Illinois Urbana-Champaign

Xin Gen Lei

Shanghai University of Traditional Chinese Medicine

Lv‐Hui Sun

Huazhong Agricultural University

Karolina Von Zuben Augusto

Trouw Nutrition (Brazil)

Mehdi Toghyani

Poultry CRC

Joshua Gong

Agriculture and Agri-Food Canada

Cooperative Institutions

Ministry of Agriculture and Rural Affairs

Chinese Academy of Agricultural Sciences

Huazhong Agricultural University

University of Illinois Urbana-Champaign

Universidade Estadual Paulista (Unesp)

Chinese Academy of Sciences

Dankook University

University of Guelph

Trouw Nutrition (Brazil)

Lanzhou University

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Hydroxychloride trace elements improved eggshell quality partly by modulating uterus histological structure and inflammatory cytokines expression in aged laying hens

Poultry Science (2021)

Qiuyu Jiang Jingjing Sun Yang He Yanbo Ma Bingkun Zhang

The objectives of this study were to investigate the effectiveness of dietary zinc, copper, and manganese hydroxychloride (HC) supplementation on performance, minerals deposition, serum parameters, eggshell ultrastructure, uterus histological structure, and inflammatory cytokines in aged hens. A total of 560 Hyline Brown layers at 62 wk of age were randomly allotted into 3 groups (CON, basal diet without extra minerals supplemented; Sulphate and HC, basal diet with sulphate or hydroxychloride zinc, copper, and manganese supplementation at levels of 80, 15, and 80 mg/kg, respectively). The trial lasted for 16 wk consisting of 4 wk depletion period and 12 wk testing period. The results indicated that dietary hydroxychloride trace elements increased egg weight (P < 0.05) when compared with CON group and improved average Haugh unit and albumen height (P < 0.05) when compared with Sulphate group from 70 to 73 wk. Trace element supplementation significantly increased eggshell strength, ceruloplasmin content in serum, and modified crystallographic structure of eggshell (P < 0.05) that included effective layer height, palisade height, mammillary layer width, and mammillary internal area ratio, but the results did not differ regarding the trace mineral sources used. Furthermore, hens fed with hydroxychloride trace element showed the highest mucosal fold height (P < 0.05) and epithelial height (P = 0.053) in eggshell gland, as well as mRNA expression of TNF-α (P < 0.05) and IL-22 (P = 0.094). It is concluded that supplementation of Zn, Cu, and Mn mixture modified eggshell quality partly through enhancing histological structure and immune responses of uterus. Hydroxychloride source of Zn, Cu, and Mn excelled sulphate in its beneficial effects for birds.

10.1016/j.psj.2021.101453

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Citations (19)

Protein and amino acid quality of meat and bone meal

Poultry Science (1997)

C.M. Parsons F. CASTANON Yanming Han

The in vivo protein quality of 14 meat and bone meals (MBM) was evaluated in three chick growth assays and a 48-h excreta collection assay using conventional and cecectomized roosters. In addition, in vitro evaluation of protein quality was assessed using pepsin N digestibility (0.2, 0.002, or 0.0002% pepsin), KOH protein solubility, and multi-enzyme pH change. Crude protein, lysine, and SAA in the MBM varied from 48 to 56, 2.32 to 3.01, and 1.0 to 2.13%, respectively. Protein efficiency ratio (weight gain:protein intake) estimated from feeding chicks diets containing 9% protein from a MBM ranged from 0.61 to 2.89 and averaged 1.78. Lysine bioavailability determined by slope-ratio chick assay ranged from 43 to 89%. True amino acid digestibility and TMEn values determined in cecectomized roosters were generally lower (P < 0.05) than those determined in conventional roosters. True digestibility of amino acids (percentage) also varied among MBM, with the mean (and range) for lysine, methionine, and cystine in cecectomized birds being 81 (73 to 88), 85 (77 to 91), and 58% (37 to 72%), respectively. Pepsin N digestibility values determined using 0.002 or 0.0002% pepsin were positively correlated (P < 0.05) with lysine digestibility. Pepsin N digestibility determined using 0.2% pepsin, KOH protein solubility, and multi-enzyme pH change were not significantly correlated with in vivo protein quality. Ash content was negatively correlated (-0.80, P < 0.05) with protein efficiency ratio. These results indicated that there is substantial variation in protein quality among commercial MBM and that pepsin N digestibility and ash content are correlated with some in vivo protein quality measurements.

Pepsin

Protein quality

10.1093/ps/76.2.361

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Citations (185)

Design and development of simulation training system for positron emission tomography/computed tomography disassembly and maintenance

Digital Medicine (2020)

Yi Xie Jing Wei Xiaomei Xie Nianyu Zhang Yanming Han

In view of the shortage of equipment resources and the inability for on-site disassembly and assembly training in the current teaching of positron emission tomography/computed tomography (PET/CT), a simulation training system for PET/CT based on Unity 3D engine and C# language is designed by 3ds Max and Cinema 4D. The system realizes the simulation interaction of the equipment, thus providing a simulation environment for the operation training of equipment disassembly and maintenance. Through practical application, more users have a great interest in learning, and the comprehensive quality of operation and maintenance ability has been significantly improved, which shows that the system effectively improves teaching quality and reduces teaching costs. Taken together, we can see that it is worth rolling out.

Economic shortage

Training System

10.4103/digm.digm_7_21

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Mitigating the adverse effects of Aflatoxin B1 in LMH, IPEC-J2 and 3D4/21 cells by a novel integrated agent

Food and Chemical Toxicology (2023)

Yixin Mo Meng-Ling Ruan Jie Wang Ying Liu Yuanyuan Wu

Occludin

Viability assay

Bcl-xL

10.1016/j.fct.2023.113907

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Citations (7)

Hydroxychloride Trace Minerals Have a Positive Effect on Growth Performance, Carcass Quality and Impact Ileal and Cecal Microbiota in Broiler Chickens

Research Square (Research Square) (2020)

Sandra van Kuijk Yanming Han A.I. García-Ruiz Ana Rodiles

Abstract Background: The objective was to study the effect of hydroxychloride trace minerals (HTM) on growth performance, carcass quality and gut microbiota of broiler chickens in comparison to sulphate trace minerals (STM). In total 1440 male Ross 308 day-old chicks were divided over 12 replicate pens with 30 birds each per treatment. Four different treatments were tested according to a 2×2 factorial study design, where the animals received a three phase diet containing either inorganic Zn from sulphates or Zn from HTM in high (80 ppm Zn) or low Zn dosage (20 ppm Zn). In all treatments 15 ppm Cu was added from the same mineral source as the Zn. Body weight and feed intake were measured on day 0, 10, 27 and 34, while carcass and breast meat yields were measured at the end of the study (day 34). In addition, high-throughput sequencing analysis was performed in digesta samples from ileum and cecum to study the gut microbiome (day 34). Results: The results showed an improved (P<0.05) body weight of broiler chickens fed HTM, regardless of Zn level, on day 27, while on day 34 this effect remained as a tendency (P= 0.0542). In the overall study period, birds fed HTM had a higher (P<0.05) average daily gain and average daily feed intake when compared to birds fed STM. The mineral source did not affect the carcass characteristics, however, feeding 80 ppm Zn resulted in a significantly higher (P=0.0171) breast meat yield, regardless of source. High-throughput sequencing analysis of the microbiota revealed a higher microbial diversity in the ileum and cecum of HTM fed birds compared to STM fed birds. Taxonomical differences were mainly found in the cecum, specifically between the group fed high and low Zn levels from HTM. This is in line with the mineral contents observed in the cecal digesta. Comparing both groups fed 80 ppm Zn, the HTM group had more Streptococcaceae, Streptococcus , Clostridia, Weissella and Leuconostocaceae compared to the STM group. Conclusions: HTM improved growth performance of the birds; and the source and level of Zn modulated the gut microbiota communities in broilers differentially.

Trace Minerals

Cecum

Lactobacillus crispatus

10.21203/rs.3.rs-65394/v1

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Pharmacokinetics, tissue distribution, and safety evaluation of a ligustilide derivative (LIGc)

Journal of Pharmaceutical and Biomedical Analysis (2020)

Yanxia Zhang Yaming Zhang Yanming Han Ye Tian Pengcheng Wu

Biodistribution

10.1016/j.jpba.2020.113140

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Effect of Feeding Rye Silage and Feed Restriction on both Growth and Reproductive Performances in Replacing Gilts

Journal of Animal Science and Technology (2006)

I Kim 김정우 김인호 J Cho Yanming Han Byeng R. Min

본 연구는 제한급여를 해야 하는 번식 후보돈에서 배합사료량을 줄이고 조사료인 호맥 사일리지를 급여하였을 때 후보돈의 생산성, 첫 발정시기, 종부시기 및 임신율에 미치는 영향을 알아보고자 실시하였다. 후보모돈(Landrace ×Yorkshire) 24두를 공시하였으며, 시험 개시시 평균체중은 67.63±1.17kg 이었고 사양시험은 49일간 실시하였다. 시험설계는 1) CON(basal diet), 2) S15(15% feed restriction+ad libitum rye silage), 3) S30(30% feed restriction+ad libitum rye silage)로 3처리로 하였다. 일당증체량과 일당사료섭취량에서는 모든 처리구에 비해 배합사료를 무제한 급여한 CON구가 가장 높았다(P<0.05). S15구와 S30구의 호맥 사일리지의 섭취량은 통계적인 차이를 보이지 않았다(P>0.05). 사료요구율에서는 CON구가 다른 처리구와 비교하여 유의적으로 낮은 결과를 보였다(P<0.05). 호맥 사일리지를 섭취한 S15와 S30처리구의 평균 호맥 사일리지 섭취량은 시간이 경과할수록 유의적으로 증가하였다(P<0.05). 임신율에 있어서는 제한급여와 호맥 사일리지를 무제한 급여한 S15구와 S30구에서 모든 후보돈이 임신하였으나, 자유채식한 CON구에서는 상대적으로 낮은 임신율을 보였다. 첫 발정시기와 종부시기에서도 호맥 사일리지를 급여한 S15구와 S30구가 대조구와 비교하여 기간이 단축되었다. This study was conducted to evaluate the effects of feeding rye silage and feed restriction on both growth and reproductive performances in replacing gilts. Twenty four replacing gilts (Landrace×Yorkshire, 67.63±1.17kg initial BW) were used in 49 d growth assay. Dietary treatments were included 1) CON(basal diet), 2) S15(15% feed restriction + ad libitum rye silage) and 3) S30(30% feed restriction + ad libitum rye silage). In growth performance, average daily gain and average daily feed intake were the highest in CON among treatments(P<0.05). Average daily silage intake was not significantly different between S15 and S30 treatments(P>0.05). Feed conversion ratio was the lowest in CON among treatments(P<0.05). Average silage intake of S15 and S30 treatments was increased as time goes by(P<0.05). While all gilts of S15 and S30 treatments became pregnant, one gilt of CON became pregnant. Also, first estrus and mating were occured earlier in S15 and S30 than those of CON. In conclusion, 15% feed restriction and feeding rye silage reduced growth performance, reached earlier to first estrus and increased pregnancy rate in replacing gilts.

Silage

10.5187/jast.2006.48.1.069

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Citations (2)

Tryptophan requirement of pigs in the weight category 10 to 20 kilograms

Journal of Animal Science (1993)

Yanming Han Thau Kiong Chung D. H. Baker

Experiments were conducted to determine the tryptophan (Trp) requirement of 10- to 20-kg pigs. A Trp-deficient experimental diet (.11% total Trp, 18% CP, 3,320 kcal of ME/kg) was composed of corn, feather meal, corn gluten meal, soybean meal, and dried whey. True digestibility of Trp in the experimental diet was 70% (.077% digestible Trp) as established in a digestibility assay that involved cecectomized, adult cockerels (Exp. 1). An initial pig study (Exp. 2) verified that the experimental basal diet, when fortified with sufficient L-Trp, was capable of producing growth rate and feed efficiency similar to that of pigs fed a conventional corn-soybean meal-dried whey diet (18% CP, 3,320 kcal of ME/kg). In Exp. 3, crossbred pigs with an average BW of 10.9 kg were fed the Trp-deficient basal diet supplemented with 0, .015, .030, .045, .060, and .075% L-Trp. In Exp. 4, crossbred pigs that averaged 9.5 kg were fed the basal diet fortified with .030, .045, .060, and .075% L-Trp. By examining the data from Exp. 3 and 4 together, the digestible Trp requirement for maximum daily weight gain was estimated to be .14% of the diet. Assuming an 88% true digestibility of Trp in commercial diets based on corn and soybean meal (calculated from published data), the total Trp required in practice would be .16% (.89% of the dietary protein).

Feather meal

Corn gluten meal

10.2527/1993.711139x

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Citations (31)

Expression Profiles of Genes in Toll-Like Receptor-Mediated Signaling of Broilers Infected with Clostridium perfringens

Clinical and Vaccine Immunology (2009)

Lu Yang Aimie J. Sarson Joshua Gong Huaijun Zhou Weiyun Zhu

Toll-like receptors (TLRs) participate in detecting microbial pattern molecules for activation of the host immune response. We investigated possible roles of TLRs in the chicken response to Clostridium perfringens infection by examining the expression of TLR genes and other genes involved in TLR-mediated signaling within the spleens and ilea of C. perfringens-challenged broilers. Upregulation of a tumor necrosis factor alpha-inducing factor homolog in challenged chickens compared to naïve chickens was observed, regardless of the incidence of necrotic enteritis. In addition, the members of the TLR2 subfamily were found to be most strongly involved in the host response to C. perfringens challenge, although the expression of TLR4 and TLR7 was also upregulated in spleen tissues. While the combination of TLR1.2, TLR2.1, and TLR15 appeared to play a major role in the splenic response, the expression of TLR2.2 and TLR1.1 was positively correlated to the expression of adaptor molecules MyD88, TRAF6, TRIF, and receptor interacting protein 1 in the ileal tissues, demonstrating a dynamic spatial and temporal innate host response to C. perfringens.

Clostridium perfringens

TRIF

TLR5

TLR7

TLR3

10.1128/cvi.00254-09

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Citations (64)

Effect of supplementing hydroxy trace minerals (Cu, Zn, and Mn) on egg quality and performance of laying hens under tropical conditions

Animal Bioscience (2023)

V. Palanisamy Sakthivel PC Lane Pineda Yanming Han

A pivotal study was designed to investigate the effect of Hydroxy (HYC) Cu, Zn, and Mn on egg quality and laying performance of chickens under tropical conditions.A total of 1,260 Babcock White laying hens (20-wk-old) were randomly assigned to one of 4 treatments with 15 replicates of 21 hens each in a Randomized Complete Block Design. The birds were reared for 16 weeks and were fed the corn-soybean meal diets supplemented with one of the following mineral treatments: T1, inorganic (INO, 15 ppm CuSO4, 80ppm MnSO4 and 80 ppm ZnO); T2, Hydroxy-nutritional level (HYC-Nut, 15 ppm Cu, 80 ppm Mn, 80 ppm Zn from Hydroxy); T3, Hydroxy-Low (HYC-Low, 15 ppm Cu, 60 ppm Mn, 60 ppm Zn from Hydroxy); T4, Hydroxy plus inorganic (HYC+INO, 7.5 ppm HYC Cu+7.5 ppm CuSO4, 40 ppm HYC ZnO+40 ppm ZnSO4, 40 ppm HYC Mn+40 ppm MnSO4). The egg production was recorded daily, while the feed consumption, feed conversion ratio (FCR) and egg mass were determined at the end of each laying period. The egg quality parameters were assayed in eggs collected over 48 h in each laying period.Overall, no significant effect of treatments was observed on percent egg production, egg weight and FCR (p>0.05). Feed intake was significantly lower in birds fed Hydroxy plus inorganic (p<0.05) diet. The supplementation of HYC-Low significantly increased the egg mass compared to the other treatments (p<0.05). HYC supplementation alone or in combination with INO elicited a positive effect on shell thickness, shell weight, shell weight per unit surface area, yolk colour, albumen and yolk index for a certain period (p<0.05), but not throughout the whole laying period.Dietary supplementation of HYC-Low (15-60-60 mg/kg) showed similar effects on production performance and egg quality characteristics in laying hens as compared to 15-80-80 mg/kg of Cu-Zn-Mn from inorganic sources. This indicates that sulphate based inorganic trace minerals can effectively be substituted by lower concentration of hydroxyl minerals.

10.5713/ab.22.0416

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Citations (4)