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Ozan Şen

İstanbul Nişantaşı Üniversitesi

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Ahmet Gökhan Türkçapar

Turkish Society of Cardiology

Matteo Uccelli

IRCCS Policlinico San Donato

Kamal Mahawar

University of Sunderland

Stefano Olmi

Vita-Salute San Raffaele University

Giovanni Dapri

Humanitas Gavazzeni

Mohammad Kermansaravi

Iran University of Medical Sciences

Hosam Elghadban

Mansoura University

Rishi Singhal

Heartlands Hospital

Nasser Sakran

University of Sfax

Mehmet Ali Yerdel

Memorial Sisli Hospital

Cooperative Institutions

University College London

University of Birmingham

Royal London Hospital

South Tyneside and Sunderland NHS Foundation Trust

Collaborative Group (United States)

Sağlık Bilimleri Üniversitesi

Ain Shams University

National Institute for Health Research

NIHR Birmingham Biomedical Research Centre

Istanbul University

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Handling of the Covid-19 Pandemic and Its Effects on Bariatric Surgical Practice: Analysis of GENEVA Study Database

Obesity Surgery (2022)

Rishi Singhal Tom Wiggins Sjaak Pouwels Yashasvi Rajeev Brijesh Madhok

The coronavirus disease 2019 (COVID-19) pandemic led to a worldwide suspension of bariatric and metabolic surgery (BMS) services. The current study analyses data on patterns of service delivery, recovery of practices, and protective measures taken during the COVID-19 pandemic by bariatric teams.The current study is a subset analysis of the GENEVA study which was an international cohort study between 01/05/2020 and 31/10/2020. Data were specifically analysed regarding the timing of BMS suspension, patterns of service recovery, and precautionary measures deployed.A total of 527 surgeons from 439 hospitals in 64 countries submitted data regarding their practices and handling of the pandemic. Smaller hospitals (with less than 200 beds) were able to restart BMS programmes more rapidly (time to BMS restart 60.8 ± 38.9 days) than larger institutions (over 2000 beds) (81.3 ± 30.5 days) (p = 0.032). There was a significant difference in the time interval between cessation/reduction and restart of bariatric services between government-funded practices (97.1 ± 76.2 days), combination practices (84.4 ± 47.9 days), and private practices (58.5 ± 38.3 days) (p < 0.001). Precautionary measures adopted included patient segregation, utilisation of personal protective equipment, and preoperative testing. Following service recovery, 40% of the surgeons operated with a reduced capacity. Twenty-two percent gave priority to long waiters, 15.4% gave priority to uncontrolled diabetics, and 7.6% prioritised patients requiring organ transplantation.This study provides global, real-world data regarding the recovery of BMS services following the COVID-19 pandemic.

Pandemic

Personal Protective Equipment

10.1007/s11695-022-06267-7

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Citations (2)

Bariatrik ve Metabolik Cerrahi Genel Prensipler ve Yenilikler II

Mustafa Taşkın Halit Eren Taşkın Seniyye Ülgen Zengin Abdülkadir Bedirli Ahmet Aslan

‘Bariatrik ve Metabolik Cerrahi Genel Prensipler ve Yenilikler’ isimli bu kitabımız bariatrik cerrahi alanında var olan temel prensiplerle beraber yeni tedavi protokolleri ve obezite cerrahisinde oluşabilecek komplikasyonlar ve uzun dönemde oluşabilecek sorunları kapsamaktadır. Bariatrik Cerrahi sadece Cerrahları değil birçok branştan hekimleri de ilgilendiren multi disipliner bir tedavi ve takip gerektiren bir cerrahi branştır. Kitabımızda beraber çalıştığımız tüm branşların tedavi ve takip protokollerine yer vermeye çalıştık. Bu eser multidisipliner ve klinik pratiklerde yaşanılan komplikasyonlara kılavuzluk edecek ilk Ulusal kitap olma özelliğini taşımaktadır. Ayrıca okuyucularına teorik eğitimin yanı sıra içerdiği vaka resimleri ile de pratik bir yol gösterici olacaktır. Bu esere katıda bulunan Obezite Cerrahisi Derneğinin üyelerine teşekkür ederiz.

10.5152/8500

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Hair Loss After Sleeve Gastrectomy and Effect of Biotin Supplements

Journal of Laparoendoscopic & Advanced Surgical Techniques (2020)

Ozan Şen Ahmet Gökhan Türkçapar

Aim: In this study, we aimed to determine the incidence of hair loss in patients who underwent laparoscopic sleeve gastrectomy (LSG), and to observe whether use of Biotin has an impact on hair loss. Methods: This study included 156 female patients who underwent LSG for obesity and completed a 1-year follow-up. All patients with vitamin deficiency were screened in the pre- and postoperative period. Hair loss was defined as the subjective perception of the women of losing a higher amount of hair when compared with normal situation. Results: Hair loss was observed in 72% of the patients after LSG (n = 112). Seventy-nine percent of the patients reported hair loss between the third and fourth-month interval, and continued for an average of 5.5 ± 2.6 months. Permanent alopecia was not observed in any of the patients. Patients who experienced hair loss and Biotin deficiency after LSG were prescribed 1000 mcg/day of Biotin for 3 months. Of these 22 patients; only 5 (23%) patients reported a remarkable decline in hair loss. İn addition, 29 patients were found to take 1000 mcg/day of Biotin for average 2.5 months after onset of hair loss by their own initiative, despite optimal blood Biotin levels. Eleven (38%) patients reported a remarkable decline in hair loss. The effect of biotin use on hair loss in patients with and without biotin deficiency was compared. There was no significant difference (P = .2). Conclusion: Temporary hair loss after LSG is common. It was found that biotin supplementation used to prevent hair loss does provide low efficacy.

Biotin deficiency

10.1089/lap.2020.0468

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Our Colonoscopic Screening Results According to Risk Groups in Colorectal Cancers (Pilot Study)

Turkish Journal of Colorectal Disease (2020)

Ozan Şen Mehmet Ayhan Kuzu

Amaç: Kolorektal kanserlerin büyük bir kısmı önceden var olan bir polip zemininde gelişir.Tarama testlerinin yaygın kullanımı ile kolorektal kanserlerin mortalitesinde azalma olduğu gösterilmiştir.Bu pilot çalışmada amacımız; kolorektal kanserlerde risk gruplarına göre bireyleri taramak ve bu yönde toplum tabanlı bilgilendirme ve tarama programlarının oluşturulmasında öncülük edecek veriler elde

Colorectal cancer screening

10.4274/tjcd.galenos.2020.2019-9-2

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Citations (1)

Genel cerrahi hastalarının ve yakınlarının bilgi arayışında internet kullanımı

Turkish Journal of Surgery (2008)

Ozan Şen Ayhan Bülent Erkek Atıl Çakmak Ulaş Sözener Cihangir Akyol

YAK

Source

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Global 30-day outcomes after bariatric surgery during the COVID-19 pandemic (GENEVA): an international cohort study

The Lancet Diabetes & Endocrinology (2020)

Rishi Singhal Abd A. Tahrani Christian Ludwig Kamal Mahawar A Abou-Mrad-Fricquegnon

Pandemic

10.1016/s2213-8587(20)30375-2

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Citations (66)

30-day morbidity and mortality of sleeve gastrectomy, Roux-en-Y gastric bypass and one anastomosis gastric bypass: a propensity score-matched analysis of the GENEVA data

International Journal of Obesity (2021)

Rishi Singhal Victor Roth Cardoso Tom Wiggins Jonathan Super Christian Ludwig

Abstract Background There is a paucity of data comparing 30-day morbidity and mortality of sleeve gastrectomy (SG), Roux-en-Y gastric bypass (RYGB), and one anastomosis gastric bypass (OAGB). This study aimed to compare the 30-day safety of SG, RYGB, and OAGB in propensity score-matched cohorts. Materials and methods This analysis utilised data collected from the GENEVA study which was a multicentre observational cohort study of bariatric and metabolic surgery (BMS) in 185 centres across 42 countries between 01/05/2022 and 31/10/2020 during the Coronavirus Disease-2019 (COVID-19) pandemic. 30-day complications were categorised according to the Clavien–Dindo classification. Patients receiving SG, RYGB, or OAGB were propensity-matched according to baseline characteristics and 30-day complications were compared between groups. Results In total, 6770 patients (SG 3983; OAGB 702; RYGB 2085) were included in this analysis. Prior to matching, RYGB was associated with highest 30-day complication rate (SG 5.8%; OAGB 7.5%; RYGB 8.0% ( p = 0.006)). On multivariate regression modelling, Insulin-dependent type 2 diabetes mellitus and hypercholesterolaemia were associated with increased 30-day complications. Being a non-smoker was associated with reduced complication rates. When compared to SG as a reference category, RYGB, but not OAGB, was associated with an increased rate of 30-day complications. A total of 702 pairs of SG and OAGB were propensity score-matched. The complication rate in the SG group was 7.3% ( n = 51) as compared to 7.5% ( n = 53) in the OAGB group ( p = 0.68). Similarly, 2085 pairs of SG and RYGB were propensity score-matched. The complication rate in the SG group was 6.1% ( n = 127) as compared to 7.9% ( n = 166) in the RYGB group ( p = 0.09). And, 702 pairs of OAGB and RYGB were matched. The complication rate in both groups was the same at 7.5 % ( n = 53; p = 0.07). Conclusions This global study found no significant difference in the 30-day morbidity and mortality of SG, RYGB, and OAGB in propensity score-matched cohorts.

Sleeve gastrectomy

Roux-en-Y anastomosis

10.1038/s41366-021-01048-1

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Citations (43)

Effect of laparoscopic sleeve gastrectomy on platelet count and mean platelet volume

Journal of Minimal Access Surgery (2023)

Ozan Şen Şeref Oray İsmail Çalıkoğlu Ümit Sekmen Ahmet Gökhan Türkçapar

Objective: Several studies have reported an increase in platelet (PLT) count with chronic inflammation in the presence of obesity. Mean platelet volume (MPV) is an important marker for PLT activity. Our study aims to demonstrate if laparoscopic sleeve gastrectomy (LSG) has any effect on PLT, MPV and white blood cells (WBCs). Methods: A total of 202 patients undergoing LSG for morbid obesity between January 2019 and March 2020 who completed at least 1 year of follow-up were included in the study. Patients’ characteristics and laboratory parameters were recorded preoperatively and were compared in the 6 th and 12 th months. Results: Two hundred and two patients (50% – female) with a mean age of 37.5 ± 12.2 years and mean pre-operative body mass index (BMI) of 43 (34.1–62.5) kg/m 2 underwent LSG. BMI regressed to 28.2 ± 4.5 kg/m 2 at 1 year after LSG ( P < 0.001). The mean PLT count, MPV and WBC during the pre-operative period were 293.2 ± 70.3 10 3 cells/μL, 10.22 ± 0.9 fL and 7.8 ± 1.9 10 3 cells/μL, respectively. A significant decrease was seen in mean PLT count, with 257.3 ± 54.2 10 3 cell/μL ( P < 0.001) at 1 year post-LSG. The mean MPV was increased at 6 months 10.5 ± 1.2 fL ( P < 0.001) and remained unchanged at 1 year 10.3 ± 1.3 fL ( P = 0.9). The mean WBC levels were significantly decreased with 6.5 ± 1.7 10 3 cells/μL ( P < 0.001) at 1 year. At the end of the follow-up, weight loss showed no correlation with PLT and MPV ( P = 0.42, P = 0.32). Conclusion: Our study has shown a significant decrease in circulating PLT and WBC levels while MPV remained unchanged after LSG.

Mean platelet volume

White blood cell

Sleeve gastrectomy

Complete blood count

10.4103/jmas.jmas_301_22

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Citations (4)

Neurological Complication After Laparoscopic Sleeve Gastrectomy: Foot Drop

Obesity Surgery (2019)

Ozan Şen Fatih Can Karaca Ahmet Gökhan Türkçapar

Sleeve gastrectomy

Foot drop

Foot (prosody)

10.1007/s11695-019-04285-6

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Citations (12)

Review of Our Experience Using Modified Staple Line Suturing Technique in Laparoscopic Sleeve Gastrectomy

Surgical Laparoscopy Endoscopy & Percutaneous Techniques (2021)

Ozan Şen Ahmet Gökhan Türkçapar

Laparoscopic sleeve gastrectomy (LSG) has become the most common bariatric surgical method in recent years. Although LSG provides good outcomes, serious complications such as leakage, bleeding, and stenosis may develop postoperatively. Numerous staple line reinforcement methods have been used to reduce complications. Whether each one of these practices is effective remains controversial.Our study aims to assess outcomes and safety of modified (purse-string+oversewing) staple line suturing technique for patients who underwent LSG.A total of 505 patients who underwent LSG with modified staple line suturing technique between March 2018 and February 2021 were included in this retrospective study. Age, sex, body mass index, operation time, perioperative and postoperative 30-day complications were recorded in all patients.Of 505 patients (59.6% female) with a mean age of 37.6 years (minimum to maximum: 12 to 68 y) and median body mass index of 40.2 kg/m2 (minimum to maximum: 32 to 75 kg/m2) underwent LSG. LSG was performed as revision surgery in 17 (3.4%) patients. Five (1%) patients also underwent concomitant cholecystectomy. The mean operation time was 92 minutes (75 to 110 min) in our primary LSG cases. Operative complications included minor hepatic injury in 8 (1.6%) and anesthesia awareness in 3 (0.6%) patients. Postoperative complications included bleeding which occurred in 2 (0.4%) patients, portomesenteric vein thrombosis in 1 (0.2%), and minor wound infection in 3 (0.6%) patients. There was no leak, no stenosis, and no mortality.Sleeve gastrectomy with modified staple line suturing technique is an effective method and could be safely applied with low morbidity.

Sleeve gastrectomy

Concomitant

10.1097/sle.0000000000001024

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Citations (4)