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Jane E. Willoughby

University of Southampton

14

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359

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Domain binding and isotype dictate the activity of anti-human OX40 antibodies.

2020 Journal for ImmunoTherapy of Cancer
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1840PPreclinical evaluation of a non-depleting, first-in-class humanized IgG4 agonist anti-ICOS antibody

2018 Annals of Oncology
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Akt signaling is critical for memory CD8+ T cell development and tumor immune surveillance

2017 Proceedings of the National Academy of Sciences of the United States of America
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Abstract IA22: Targeting inducible T cell co-stimulator (ICOS) promotes effector T cell function and antitumor response

2016 Cancer immunology research
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Abstract B055: Augmentation of OX40-dependent NK mediated antitumor activity is dependent on antibody cross-linking

2016 Cancer immunology research
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Conformation of the Human Immunoglobulin G2 Hinge Imparts Superagonistic Properties to Immunostimulatory Anticancer Antibodies

2015 Cancer Cell
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Differential Impact of CD27 and 4-1BB Costimulation on Effector and Memory CD8 T Cell Generation following Peptide Immunization

2014 Journal of Immunology
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Sustained TL1A expression modulates effector and regulatory T-cell responses and drives intestinal goblet cell hyperplasia

2011 Mucosal Immunology
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Citations (69)