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Ruth R. French

University of Southampton
Southampton General Hospital

68

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On-target IgG hexamerisation driven by a C-terminal IgM tail-piece fusion variant confers augmented complement activation.

2021
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Isotype Switching Converts Anti-CD40 Antagonism to Agonism to Elicit Potent Antitumor Activity.

2020 Cancer Cell
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Immunological Methods to Study Monoclonal Antibody Activity in Chronic Lymphocytic Leukaemia

2019 Methods of Molecular Biology
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Effector mechanisms of IgA antibodies against CD20 include recruitment of myeloid cells for antibody‐dependent cell‐mediated cytotoxicity and complement‐dependent cytotoxicity

2018 British Journal of Haematology
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Complex Interplay between Epitope Specificity and Isotype Dictates the Biological Activity of Anti-human CD40 Antibodies

2018 Cancer Cell
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Upregulation of FcγRIIb on monocytes is necessary to promote the superagonist activity of TGN1412

2015 Blood
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Antigenic modulation limits the effector cell mechanisms employed by type I anti-CD20 monoclonal antibodies.

2015 Blood
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Anti-mouse Fc?RIV antibody 9E9 also blocks Fc?RIII in vivo

2015 Blood
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Anti-mouse FcγRIV antibody 9E9 also blocks FcγRIII in vivo.

2015 Blood
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Conformation of the Human Immunoglobulin G2 Hinge Imparts Superagonistic Properties to Immunostimulatory Anticancer Antibodies

2015 Cancer Cell
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Citations (102)