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Karl J. Mathis

Pfizer

19

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479

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MMP-13 selective α-sulfone hydroxamates: a survey of P1' heterocyclic amide isosteres.

2011 Bioorganic & Medicinal Chemistry Letters
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Structure analysis reveals the flexibility of the ADAMTS-5 active site.

2011 Protein Science
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MMP-13 in complex with selective tetrazole core inhibitor

2011
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Structure-based drug design enables conversion of a DFG-in binding CSF-1R kinase inhibitor to a DFG-out binding mode.

2010 Bioorganic & Medicinal Chemistry Letters
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Inhibitor Bound to A DFG-Out structure of the Kinase Domain of CSF-1R

2010
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Orally Active MMP-1 Sparing α-Tetrahydropyranyl and α-Piperidinyl Sulfone Matrix Metalloproteinase (MMP) Inhibitors with Efficacy in Cancer, Arthritis, and Cardiovascular Disease

2010 Journal of Medicinal Chemistry
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CDK-2 with indazole inhibitor 17 bound at its active site

2009
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2-(6-Phenyl-1H-indazol-3-yl)-1H-benzo[d]imidazoles: Design and synthesis of a potent and isoform selective PKC-[zeta] inhibitor

2009 Bioorganic & Medicinal Chemistry Letters
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Crystal Structure of the Catalytic Domain of ADAMTS-5 in Complex with Marimastat

2009
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Crystal Structure of the Catalytic Domain of ADAMTS-5 in Complex with an Amino-2-indanol compound

2009
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