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Hong Cheng

Novartis

15

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1760

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Abstract 5472: Basal-like breast cancer subtype is characterized by deregulated glutamine metabolism and is sensitive to GLS inhibition

2018 Cancer Research
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A Robust Multiplex Mass Spectrometric Assay for Screening Small-Molecule Inhibitors of CD73 with Diverse Inhibition Modalities:

2018
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Glutaminase is essential for the growth of triple-negative breast cancer cells with a deregulated glutamine metabolism pathway and its suppression synergizes with mTOR inhibition

2017 PLOS ONE
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Combination of PIM and JAK2 inhibitors synergistically suppresses cell proliferation and overcomes drug resistance of myeloproliferative neoplasms

2014 Oncotarget
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Abstract 5468: SAR650984, a humanized anti-CD38 antibody potently modulates intracellular and extracellular nucleotide levels of cancer cells

2014 Cancer Research
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Evaluation of cancer dependence and druggability of PRP4 kinase using cellular, biochemical, and structural approaches

2013 Journal of Biological Chemistry
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[1,2,4]triazol-3-ylsulfanylmethyl)-3-phenyl-[1,2,4]oxadiazoles: antagonists of the Wnt pathway that inhibit tankyrases 1 and 2 via novel adenosine pocket binding.

2012 Journal of Medicinal Chemistry
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Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling

2009 Nature
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