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Joe Lyssikatos

10

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Investigating small molecules to inhibit germinal center kinase-like kinase (GLK/MAP4K3) upstream of PKCθ phosphorylation: Potential therapy to modulate T cell dependent immunity.

2018 Bioorganic & Medicinal Chemistry Letters
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Biological Characterization of ARRY-142886 (AZD6244), a Potent, Highly Selective Mitogen-Activated Protein Kinase Kinase 1/2 Inhibitor

2007 Clinical Cancer Research
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ARRY-649, a member of a novel class of Eg5 kinesin inhibitors

2006 Journal of Clinical Oncology
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ARRY-429520, a Novel KSP Inhibitor with Potent Anti-Proliferative Activity in Leukemic Cell Lines.

2006 Blood
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ARRY-334543, A potent, orally active small molecule inhibitor of EGFR and ErbB-2

2005 Cancer Research
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Validation and use of a biomarker for clinical development of the MEK1/2 inhibitor ARRY-142886 (AZD6244)

2005 Journal of Clinical Oncology
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ARRY-142886, a potent and selective MEK inhibitor: III) Efficacy in murine xenograft models correlates with decreased ERK phosphorylation

2004 Cancer Research
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Preclinical development of ARRY-142886, a potent and selective MEK inhibitor

2004 Cancer Research
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342 Anti-tumor activity, pharmacokinetic and pharmacodynamic effects of the MEK inhibitor ARRY-142886 (AZD6244) in a BxPC3 pancreatic tumor xenograft model

2004 Ejc Supplements
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