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Darin Smith

Raytheon

15

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757

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Identification of the Clinical Development Candidate MRTX849, a Covalent KRAS(G12C) Inhibitor for the Treatment of Cancer.

2020 Journal of Medicinal Chemistry
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Activation loop dynamics are controlled by conformation-selective inhibitors of ERK2.

2019 Proceedings of the National Academy of Sciences of the United States of America
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High Temperature CMOS Circuits on Silicon Carbide

2015 Materials Science Forum
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8-Tetrahydropyran-2-yl Chromans: Highly Selective Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitors

2014 Journal of Medicinal Chemistry
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Diethylaminosulfur Trifluoride-Mediated Intramolecular Cyclization of 2-hydroxycycloalkylureas to Fused Bicyclic Aminooxazoline Compounds and Evaluation of Their Biochemical Activity Against β-Secretase-1 (BACE-1)

2013 Tetrahedron Letters
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Non-charged thiamine analogs as inhibitors of enzyme transketolase.

2008 Bioorganic & Medicinal Chemistry Letters
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Biological Characterization of ARRY-142886 (AZD6244), a Potent, Highly Selective Mitogen-Activated Protein Kinase Kinase 1/2 Inhibitor

2007 Clinical Cancer Research
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Preclinical development of ARRY-142886, a potent and selective MEK inhibitor

2004 Cancer Research
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