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Sophie Mukadam

Genentech

13

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373

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BB-301: A Silence and Replace AAV-Based Vector for the Treatment of Oculopharyngeal Muscular Dystrophy

2021 Molecular therapy. Nucleic acids
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Preclinical assessment of the ADME, efficacy and drug-drug interaction potential of a novel NAMPT inhibitor

2019 Xenobiotica
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In vitro and in vivo characterization of CYP inhibition by 1-aminobenzotriazole in rats

2016 Biopharmaceutics & Drug Disposition
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Physiologically Based Pharmacokinetic Modeling as a Tool to Predict Drug Interactions for Antibody-Drug Conjugates

2015 Clinical Pharmacokinectics
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1-Aminobenzotriazole Coincubated with (S)-Warfarin Results in Potent Inactivation of CYP2C9

2014 Drug Metabolism and Disposition
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Discovery and Biological Profiling of Potent and Selective mTOR Inhibitor GDC-0349.

2013 ACS Medicinal Chemistry Letters
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Discovery of potent and efficacious urea-containing nicotinamide phosphoribosyltransferase (NAMPT) inhibitors with reduced CYP2C9 inhibition properties.

2013 Bioorganic & Medicinal Chemistry Letters
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Application of IVIVE and PBPK modeling in prospective prediction of clinical pharmacokinetics: strategy and approach during the drug discovery phase with four case studies

2012 Biopharmaceutics & Drug Disposition
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Evaluation of Time-Dependent Cytochrome P450 Inhibition in a High-Throughput, Automated Assay: Introducing a Novel Area Under the Curve Shift Approach

2012 Drug Metabolism Letters
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Assessment of the induction of systemic clearance vs. first-pass effect of Midazolam (MDZ) using a physiologically-based dynamic model

2012
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