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Thomas OBrien

Genentech

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Double genetic disruption of lactate dehydrogenases A and B is required to ablate the

2018
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Double genetic disruption of lactate dehydrogenases A and B is required to ablate the “Warburg effect” restricting tumor growth to oxidative metabolism

2018 Journal of Biological Chemistry
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Monitoring and Targeting Anti-VEGF Induced Hypoxia within the Viable Tumor by 19F–MRI and Multispectral Analysis

2017 Neoplasia
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Abstract P3-04-24: Identification of preclinical mechanisms driving acquired resistance to selective ERa degraders (SERDs), CDK4/6 inhibitors, or to combinations of both agents

2017 Cancer Research
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Abstract 1803: Breast cancer cell lines with acquired resistance to selective ERα degraders (SERDs) are dependent on PI3K signaling

2016 Cancer Research
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Minimizing CYP2C9 Inhibition of Exposed-Pyridine NAMPT (Nicotinamide Phosphoribosyltransferase) Inhibitors.

2016 Journal of Medicinal Chemistry
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Chemically Diverse Group I p21-Activated Kinase (PAK) Inhibitors Impart Acute Cardiovascular Toxicity with a Narrow Therapeutic Window

2016 Journal of Medicinal Chemistry
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Metabolic plasticity underpins innate and acquired resistance to LDHA inhibition

2016 Nature Chemical Biology
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Metabolite profiling stratifies pancreatic ductal adenocarcinomas into subtypes with distinct sensitivities to metabolic inhibitors

2015 Proceedings of the National Academy of Sciences of the United States of America
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Retinal Toxicity, in vivo and in vitro, Associated with Inhibition of Nicotinamide Phosphoribosyltransferase

2015 Toxicological Sciences
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