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Frances Emms

Merck & Co.

20

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1038

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4-N-linked-heterocyclic piperidine derivatives with high affinity and selectivity for human dopamine D4 receptors

1999 Bioorganic & Medicinal Chemistry Letters
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Regional Differences in the Inhibition of Mouse In Vivo [3H]Ro 15-1788 Binding Reflect Selectivity for α1 versus α2 and α3 Subunit-Containing GABAA Receptors

1999 Neuropsychopharmacology
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1-(3-Cyanobenzylpiperidin-4-yl)-5-methyl-4-phenyl-1,3-dihydroimidazol-2-one : A selective high-affinity antagonist for the human dopamine D4receptor with excellent selectivity over ion channels

1999 Journal of Medicinal Chemistry
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3-(1-Piperazinyl)-4,5-dihydro-1H-benzo[g]indazoles: high affinity ligands for the human dopamine D4 receptor with improved selectivity over ion channels

1998 Bioorganic & Medicinal Chemistry
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Photoaffinity labeling of the benzodiazepine binding site of alpha1beta3gamma2 gamma-aminobutyric acidA receptors with flunitrazepam identifies a subset of ligands that interact directly with His102 of the alpha subunit and predicts orientation of these within the benzodiazepine pharmacophore.

1998 Molecular Pharmacology
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Binding of 2,4-disubstituted morpholines at human D4 dopamine receptors.

1998 Bioorganic & Medicinal Chemistry
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4-Heterocyclyl tetrahydropyridines as selective ligands for the human dopamine D4 receptor

1997 Bioorganic & Medicinal Chemistry Letters
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Biological profile of L-745,870, a selective antagonist with high affinity for the dopamine D4 receptor.

1997 Journal of Pharmacology and Experimental Therapeutics
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Identification and pharmacological characterization of [125I]L-750,667, a novel radioligand for the dopamine D4 receptor.

1996 Molecular Pharmacology
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Antagonism oftheeffects of(+)-PD128907 on midbrain dopamine neuronesinratbrain slices byaselective D2receptor antagonist L-741,626

1996
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