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Desmond O’Connor

Merck & Co.

28

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1463

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Non-basic ligands for aminergic GPCRs: the discovery and development diaryl sulfones as selective, orally bioavailable 5-HT2A receptor antagonists for the treatment of sleep disorders.

2010 Bioorganic & Medicinal Chemistry Letters
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Hyphenated Techniques in Drug Discovery: Purity Assessment, Purification, Quantitative Analysis and Metabolite Identification

2009
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In vitro and in vivo properties of 3-tert-butyl-7-(5-methylisoxazol-3-yl)-2-(1-methyl-1H-1,2,4-triazol-5-ylmethoxy)-pyrazolo[1,5-d]-[1,2,4]triazine (MRK-016), a GABAA receptor alpha5 subtype-selective inverse agonist

2009 Journal of Pharmacology and Experimental Therapeutics
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High-throughput bioanalysis with simultaneous acquisition of metabolic route data using ultra performance liquid chromatography coupled with time-of-flight mass spectrometry

2006 Analytical and Bioanalytical Chemistry
- Desmond O’Connor
- Russell J. Mortishire-Smith
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‘All-in-One’ analysis for metabolite identification using liquid chromatography/hybrid quadrupole time-of-flight mass spectrometry with collision energy switching

2005 Rapid Communications in Mass Spectrometry
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Assessment of modafinil on attentional processes in a five-choice serial reaction time test in the rat

2005 Journal of Psychopharmacology
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Accelerated throughput metabolic route screening in early drug discovery using high-resolution liquid chromatography/quadrupole time-of-flight mass spectrometry and automated data analysis

2005 Rapid Communications in Mass Spectrometry
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Selective, Orally Active γ-Aminobutyric AcidA α5 Receptor Inverse Agonists as Cognition Enhancers

2004 Journal of Medicinal Chemistry
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3-Phenyl-6-(2-pyridyl)methyloxy-1,2,4-triazolo[3,4-a]phthalazines and Analogues: High-Affinity γ-Aminobutyric Acid-A Benzodiazepine Receptor Ligands with α2, α3, and α5-Subtype Binding Selectivity over α1

2004 Journal of Medicinal Chemistry
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P-Glycoprotein efflux reduces the brain concentration of the substance P (NK1 receptor) antagonists SR140333 and GR205171: a comparative study using mdr1a-/- and mdr1a+/+ mice.

2003 Behavioural Pharmacology
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Citations (17)