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Wolfgang Haap

Hoffmann-La Roche

41

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What We Learned in 25 Years of Interactive Molecular Design Sessions.

2021 ChemMedChem
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DOTAM-Based, Targeted, Activatable Fluorescent Probes for the Highly Sensitive and Selective Detection of Cancer Cells.

2021 Bioconjugate Chemistry
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Repurposing a Library of Human Cathepsin L Ligands: Identification of Macrocyclic Lactams as Potent Rhodesain and Trypanosoma brucei Inhibitors.

2018 Journal of Medicinal Chemistry
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Cathepsin S inhibition suppresses autoimmune-triggered inflammatory responses in macrophages

2017 Biochemical Pharmacology
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Cathepsin S inhibition combines control of systemic and peripheral pathomechanisms of autoimmune tissue injury

2017 Scientific Reports
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Discovery of Fluoromethylketone-Based Peptidomimetics as Covalent ATG4B (Autophagin-1) Inhibitors

2016 ACS Medicinal Chemistry Letters
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P36 CATHEPSIN-S INHIBITION HAS A DUAL THERAPEUTIC EFFECT ON THE SYSTEMIC AND PERIPHERAL PATHOMECHANISMS OF LUPUS NEPHRITIS

2016 Kidney International Reports
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Selective Cathepsin S Inhibition Attenuates Atherosclerosis in Apolipoprotein E–Deficient Mice with Chronic Renal Disease

2015 American Journal of Pathology
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Cathepsin S inhibition suppresses systemic lupus erythematosus and lupus nephritis because cathepsin S is essential for MHC class II-mediated CD4 T cell and B cell priming

2015 Annals of the Rheumatic Diseases
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Determination of protein-ligand binding constants of a cooperatively regulated tetrameric enzyme using electrospray mass spectrometry.

2014 ACS Chemical Biology
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