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Johannes Aebi

Hoffmann-La Roche

59

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1423

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Discovery of 3-Pyridyl Isoindolin-1-one Derivatives as Potent, Selective and Orally Active Aldosterone Synthase (CYP11B2) Inhibitors.

2020 Journal of Medicinal Chemistry
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Targeted gamma-secretase inhibition of Notch signaling activation in acute renal injury

2018 American Journal of Physiology-renal Physiology
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Ligand channel in pharmacologically stabilized rhodopsin.

2018 Proceedings of the National Academy of Sciences of the United States of America
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Discovery of Fluoromethylketone-Based Peptidomimetics as Covalent ATG4B (Autophagin-1) Inhibitors

2016 ACS Medicinal Chemistry Letters
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Synthesis of annulated pyridines as inhibitors of aldosterone synthase (CYP11B2)

2016 Organic and Biomolecular Chemistry
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Abstract 3789: Targeting cholesterol biosynthesis pathway to inhibit growth of drug resistant ovarian cancer cells

2016 Cancer Research
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Discovery of 4-Aryl-5,6,7,8-tetrahydroisoquinolines as Potent, Selective, and Orally Active Aldosterone Synthase (CYP11B2) Inhibitors: In Vivo Evaluation in Rodents and Cynomolgus Monkeys.

2015 Journal of Medicinal Chemistry
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Flow synthesis of annulated 5-aryl-substituted pyridines by tandem intramolecular inverse-electron-demand hetero-/retro-Diels–Alder reaction

2013 Tetrahedron Letters
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Flow synthesis of annulated 5-aryl-substituted pyridines by tandem intramolecular inverse-electron-demand hetero-/retro-Diels–Alder reaction

2013 Tetrahedron Letters
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Cytotoxic effects of combination of oxidosqualene cyclase inhibitors with atorvastatin in human cancer cells.

2012 Journal of Medicinal Chemistry
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Citations (18)