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Jacob M. Hoffman

Merck & Co.

10

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An allosteric Akt inhibitor effectively blocks Akt signaling and tumor growth with only transient effects on glucose and insulin levels in vivo

2010 Cancer Biology & Therapy
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Allosteric inhibitors of Akt1 and Akt2: a naphthyridinone with efficacy in an A2780 tumor xenograft model.

2008 Bioorganic & Medicinal Chemistry Letters
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A practical synthesis of 5‐(chloromethyl)furo[2,3‐b]pyridine, a key intermediate for the HIV protease inhibitor, L‐754,394

1995 Journal of Heterocyclic Chemistry
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Synthesis and evaluation of 2-pyridinone derivatives as HIV-1-specific reverse transcriptase inhibitors. 4. 3-[2-(Benzoxazol-2-yl)ethyl]-5-ethyl-6-methylpyridin-2(1H)-one and analogues.

1993 Journal of Medicinal Chemistry
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Pyridinone derivatives: specific human immunodeficiency virus type 1 reverse transcriptase inhibitors with antiviral activity.

1991 Proceedings of the National Academy of Sciences of the United States of America
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Topically active carbonic anhydrase inhibitors. 1. O-Acyl derivatives of 6-hydroxybenzothiazole-2-sulfonamide

1989 Journal of Medicinal Chemistry
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Topically active carbonic anhydrase inhibitors. 2. Benzo[b]thiophenesulfonamide derivatives with ocular hypotensive activity.

1989 Journal of Medicinal Chemistry
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Structure-activity, theoretical, and X-ray studies on the intramolecular interactions in a series of novel histamine H2 receptor antagonists.

1984 Journal of Medicinal Chemistry
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4‐Alkyl(aryl)‐3‐amino‐1,2,5‐thiadiazole 1,1‐dioxides

1983 Journal of Heterocyclic Chemistry
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Citations (10)