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Toshitake Kobayashi
Toshitake Kobayashi
Takeda Pharmaceutical Company
Biochemistry
Chemistry
Receptor
Hormone
Orphan receptor
4
Papers
84
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2024
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Design, Synthesis, and Evaluation of the Highly Selective and Potent G-Protein-Coupled Receptor Kinase 2 (GRK2) Inhibitor for the Potential Treatment of Heart Failure
2017
Journal of Medicinal Chemistry
Tomohiro Okawa
Yoshio Aramaki
Mitsuo Yamamoto
Toshitake Kobayashi
Shoji Fukumoto
Yukio Toyoda
Tsutomu Henta
Akito Hata
Shota Ikeda
Manami Kaneko
Isaac D. Hoffman
Bi-Ching Sang
Hua Zou
Tetsuji Kawamoto
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Citations (27)
Fragment-based drug discovery of potent and selective MKK3/6 inhibitors.
2016
Bioorganic & Medicinal Chemistry Letters
Mark E. Adams
Toshitake Kobayashi
J. David Lawson
Morihisa Saitoh
Kenichiro Shimokawa
Simone V. Bigi
Mark S. Hixon
Christopher Smith
Takayuki Tatamiya
Masayuki Goto
Joseph Russo
Charles E. Grimshaw
Steven Swann
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Citations (13)
2-acylamino-4,6-diphenylpyridine derivatives as novel GPR54 antagonists with good brain exposure and in vivo efficacy for plasma LH level in male rats.
2010
Bioorganic & Medicinal Chemistry
Toshitake Kobayashi
Satoshi Sasaki
Naoki Tomita
Seiji Fukui
Masaharu Nakayama
Atsushi Kiba
Masami Kusaka
Shin-ichi Matsumoto
Masashi Yamaguchi
Fumio Itoh
Atsuo Baba
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Citations (18)
Synthesis and structure-activity relationships of 2-acylamino-4,6-diphenylpyridine derivatives as novel antagonists of GPR54.
2010
Bioorganic & Medicinal Chemistry
Toshitake Kobayashi
Satoshi Sasaki
Naoki Tomita
Seiji Fukui
Noritaka Kuroda
Masaharu Nakayama
Atsushi Kiba
Yoshihiro Takatsu
Tetsuya Ohtaki
Fumio Itoh
Atsuo Baba
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Citations (26)
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