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Tracy Haldiman

Case Western Reserve University

18

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543

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Diverse, evolving conformer populations drive distinct phenotypes in frontotemporal lobar degeneration caused by the same MAPT-P301L mutation.

2020 Acta Neuropathologica
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Chronic wasting disease (CWD) prion strains evolve via adaptive diversification of conformers in hosts expressing prion protein polymorphisms.

2020 Journal of Biological Chemistry
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Artificial strain of human prions created in vitro

2018 Nature Communications
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ALTERED PROTEIN EXPRESSION IN AMYLOID PLAQUES IN RAPIDLY PROGRESSIVE ALZHEIMER’S DISEASE

2016 Alzheimers & Dementia
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Schematic representation of PK-resistant fragments in rPrP Sc corresponding to Type 1 (MM1) and Type 2 (MM2) sCJD prions and molecular characteristics of purified human rPrPSc used in structural studies.

2015 PLOS Pathogens
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Structural Determinants of Phenotypic Diversity and Replication Rate of Human Prions

2015 PLOS Pathogens
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Source, biophysical characteristics, and replication rate of Type 1 and Type 2 sCJD prions.

2015 PLOS Pathogens
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Rapidly progressive Alzheimer's disease features distinct structures of amyloid-β.

2015 Brain
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Prion Infectivity Plateaus and Conversion to Symptomatic Disease Originate from Falling Precursor Levels and Increased Levels of Oligomeric PrPSc Species.

2015 Journal of Virology
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DISTINCT STRUCTURES OF B-AMYLOID IN RAPIDLY PROGRESSIVE ALZHEIMER DISEASE

2014 Alzheimers & Dementia
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