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Hiroyuki Sumi

Takeda Pharmaceutical Company

15

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129

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Design and synthesis of a monocyclic derivative as a selective ACC1 inhibitor by chemical modification of biphenyl ACC1/2 dual inhibitors.

2021 Bioorganic & Medicinal Chemistry
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The Identification and Pharmacological Evaluation of Potent, Selective and Orally Available ACC1 Inhibitor

2019 Bioorganic & Medicinal Chemistry Letters
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Discovery of Novel Selective Acetyl-CoA Carboxylase (ACC) 1 Inhibitors

2018 Journal of Medicinal Chemistry
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Feedback activation of AMPK-mediated autophagy acceleration is a key resistance mechanism against SCD1 inhibitor-induced cell growth inhibition

2017 PLOS ONE
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T-3256336, a novel and orally available small molecule IAP antagonist, induced tumor cell death via induction of systemic TNF alpha production

2016 Biochemical and Biophysical Research Communications
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Design and Synthesis of Potent Inhibitor of Apoptosis (IAP) Proteins Antagonists Bearing an Octahydropyrrolo[1,2-a]pyrazine Scaffold as a Novel Proline Mimetic.

2013 Journal of Medicinal Chemistry
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Antitumor Activity and Pharmacodynamic Biomarkers of a Novel and Orally Available Small-Molecule Antagonist of Inhibitor of Apoptosis Proteins

2013 Molecular Cancer Therapeutics
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