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Pekka Patrikainen
Pekka Patrikainen
Cell adhesion
Biochemistry
Collagen receptor
Integrin
Chemistry
2
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18
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Structure of Collagen Receptor Integrin α1I Domain Carrying the Activating Mutation E317A
2011
Journal of Biological Chemistry
Matti Lahti
Eva Bligt
Henri Niskanen
Vimal Parkash
Anna Maria Brandt
Johanna Jokinen
Pekka Patrikainen
Jarmo Käpylä
Jyrki Heino
Tiina A. Salminen
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Background: The integrin I domain undergoes a conformational change during activation. Results: The crystal structure of an activated I domain is different from the reported open and closed states. Conclusion: Our structure mimics the state where the Arg 287 -Glu 317 ion pair is just broken during the activation process. Significance: The activation mechanism of the collagen receptor integrins differs from the other integrins.
2011
Matti Lahti
Eva Bligt
Henri Niskanen
Vimal Parkash
Anna Maria Brandt
Johanna Jokinen
Pekka Patrikainen
Jarmo Käpylä
Jyrki Heino
Tiina A. Salminen
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