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R. Matico

GlaxoSmithKline

46

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Characterization of apo‐form selective inhibition of indoleamine 2,3‐dioxygenase.

2020 ChemBioChem
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Characterization of novel inhibition of indoleamine 2,3-dioxygenase by targeting its apo form.

2018 bioRxiv
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Transition state for the NSD2-catalyzed methylation of histone H3 lysine 36

2016 Proceedings of the National Academy of Sciences of the United States of America
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Nucleosome Binding Alters the Substrate Bonding Environment of Histone H3 Lysine 36 Methyltransferase NSD2

2016 Journal of the American Chemical Society
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Crystal Structure of murine 12F4 Fab monoclonal antibody against ADAMTS5

2015
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Translational development of an ADAMTS-5 antibody for osteoarthritis disease modification

2015 Osteoarthritis and Cartilage
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Abstract 4357: Key differences revealed in NSD2 kinetics using truncated versus full-length protein

2015 Cancer Research
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The highs and lows of translational drug development: antibody-mediated inhibition of ADAMTS-5 for osteoarthritis disease modification

2014 Osteoarthritis and Cartilage
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Discovery of Highly Potent and Selective Small Molecule ADAMTS-5 Inhibitors That Inhibit Human Cartilage Degradation via Encoded Library Technology (ELT)

2012 Journal of Medicinal Chemistry
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Bace-1 Inhibitors Using Novel Edge-to-Face Interaction with Arg-296

2010 Bioorganic & Medicinal Chemistry Letters
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Citations (9)