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Douglas Hedley

Institute of Cancer Research

18

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1375

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Directed Enzyme Prodrug Therapies

2011
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A Novel, Selective and Efficacious Nanomolar Pyridopyrazinone Inhibitor of V600EBRAF

2010 Cancer Research
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Development of Novel, Highly Potent Inhibitors of V-RAF Murine Sarcoma Viral Oncogene Homologue B1 (BRAF): Increasing Cellular Potency through Optimization of a Distal Heteroaromatic Group

2010 Journal of Medicinal Chemistry
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Novel hinge binder improves activity and pharmacokinetic properties of BRAF inhibitors.

2010 Journal of Medicinal Chemistry
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Inducible expression of V600E Braf using tyrosinase-driven Cre recombinase results in embryonic lethality

2010 Pigment Cell & Melanoma Research
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Corrections to Pyridoimidazolones as Novel Potent Inhibitors of v-Raf Murine Sarcoma Viral Oncogene Homologue B1 (BRAF)

2009 Journal of Medicinal Chemistry
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Pyridoimidazolones as Novel Potent Inhibitors of v-Raf Murine Sarcoma Viral Oncogene Homologue B1 (BRAF)

2009 Journal of Medicinal Chemistry
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Attenuated Salmonella targets prodrug activating enzyme carboxypeptidase G2 to mouse melanoma and human breast and colon carcinomas for effective suicide gene therapy.

2008 Clinical Cancer Research
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Carboxypeptidase G2-based gene-directed enzyme–prodrug therapy: a new weapon in the GDEPT armoury

2007 Nature Reviews Cancer
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Suicide Gene Therapy of Human Colon Carcinoma Xenografts Using an Armed Oncolytic Adenovirus Expressing Carboxypeptidase G2

2007 Cancer Research
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Citations (55)