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Leona E. Ling

Biogen Idec

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968 Estimation of hemolytic disease of the newborn in the United States from 1996-2010

2021 American Journal of Obstetrics and Gynecology
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Effect of the loss of the type III TGFβ receptor during tumor progression on tumor microenvironment: Preclinical development of TGFβ inhibition and TGFβ-related biomarkers to enhance immunotherapy efficacy.

2017 Journal of Clinical Oncology
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STAT3 Signaling Is Required for Optimal Regression of Large Established Tumors in Mice Treated with Anti-OX40 and TGFβ Receptor Blockade

2015 Cancer immunology research
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STAT3 signaling is required for anti-OX40/TGF-β receptor blockade-mediated regression of large established tumors

2013 Journal for ImmunoTherapy of Cancer
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Type III TGF-β receptor downregulation generates an immunotolerant tumor microenvironment

2013 Journal of Clinical Investigation
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Structure-based design of 2,6,7-trisubstituted-7H-pyrrolo[2,3-d]pyrimidines as Aurora kinases inhibitors.

2012 Bioorganic & Medicinal Chemistry Letters
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Abstract 3548: Loss of the type III TGF-β receptor during cancer progression generates an immunotolerant tumor microenvironment: Translational implications for TGF-β inhibition and immunotherapy biomarker development

2012 Cancer Research
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Synthesis, SAR and biological evaluation of 1,6-disubstituted-1H-pyrazolo[3,4-d]pyrimidines as dual inhibitors of Aurora kinases and CDK1.

2012 Bioorganic & Medicinal Chemistry Letters
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The small molecule TGF-β signaling inhibitor SM16 synergizes with agonistic OX40 antibody to suppress established mammary tumors and reduce spontaneous metastasis

2012 Cancer Immunology, Immunotherapy
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Design, synthesis, and biological evaluation of pyrazolopyrimidine-sulfonamides as potent multiple-mitotic kinase (MMK) inhibitors (part I).

2011 Bioorganic & Medicinal Chemistry Letters
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