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Debra D. Pittman

Genetics Institute, Inc.

14

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The factor V B-domain provides two functions to facilitate thrombin cleavage and release of the light chain

1995 Blood
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Role of the B domain for factor VIII and factor V expression and function

1994 Blood
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Site-directed mutagenesis and expression of coagulation factors VIII and V in mammalian cells

1993 Methods in Enzymology
- Debra D. Pittman
- Randal J. Kaufman
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A2 domain of human recombinant-derived factor VIII is required for procoagulant activity but not for thrombin cleavage.

1992 Blood
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The role of von Willebrand factor multimers and propeptide cleavage in binding and stabilization of factor VIII.

1991 Journal of Biological Chemistry
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Cloning and expression in COS-1 cells of a full-length cDNA encoding human coagulation factor X.

1991 Gene
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Structure-function relationships of factor VIII elucidated through recombinant DNA technology.

1989 Thrombosis and Haemostasis
- Debra D. Pittman
- Randal J. Kaufman
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Citations (48)