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Angus Murray Macleod

Merck & Co.

98

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Preparation of sulfonylureas, especially N-[(1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)carbamoyl]benzenesulfonamides, as dual insulin secretagogues and NLRP3 inflammasome inhibitors.

2017
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Sulfonylureas and related compounds and use of the same

2016
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Identification of an Orally Bioavailable, Potent, and Selective Inhibitor of GlyT1.

2010 ACS Medicinal Chemistry Letters
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Non-basic ligands for aminergic GPCRs: the discovery and development diaryl sulfones as selective, orally bioavailable 5-HT2A receptor antagonists for the treatment of sleep disorders.

2010 Bioorganic & Medicinal Chemistry Letters
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In Vitro and in Vivo Properties of 3-tert-Butyl-7-(5-methylisoxazol-

2009
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In vitro and in vivo properties of 3-tert-butyl-7-(5-methylisoxazol-3-yl)-2-(1-methyl-1H-1,2,4-triazol-5-ylmethoxy)-pyrazolo[1,5-d]-[1,2,4]triazine (MRK-016), a GABAA receptor alpha5 subtype-selective inverse agonist

2009 Journal of Pharmacology and Experimental Therapeutics
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Triazolopyrazinforbindelser which can be used for the treatment of degenerative and inflammatory diseases

2007
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2,5-Disubstituted Pyridines: The Discovery of a Novel Series of 5-HT2A Ligands.

2007 ChemInform
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An Inverse Agonist Selective for 5 Subunit-Containing GABAA Receptors Enhances Cognition

2006
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A new class of selective, non-basic 5-HT2A receptor antagonists

2006 Bioorganic & Medicinal Chemistry Letters
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Citations (22)