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Jin-Jun Liu

Hoffmann-La Roche

22

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Discovery of Potent and Orally Active p53-MDM2 Inhibitors RO5353 and RO2468 for Potential Clinical Development

2014 ACS Medicinal Chemistry Letters
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Discovery of potent and selective spiroindolinone MDM2 inhibitor, RO8994, for cancer therapy

2014 Bioorganic & Medicinal Chemistry
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Discovery of RG7388, a Potent and Selective p53–MDM2 Inhibitor in Clinical Development

2013 Journal of Medicinal Chemistry
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Dérivés de 3-cyano-1-hydroxyméthyl-2-phénylpyrrolidine en tant qu'inhibiteurs des interactions mdm2-p53 utiles pour le traitement de cancer

2011
- Jin-Jun Liu
- Tina Morgan Ross
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Preclinical evaluation of the novel multi-targeted agent R1530

2011 Cancer Chemotherapy and Pharmacology
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Small-molecule inducer of cancer cell polyploidy promotes apoptosis or senescence: Implications for therapy

2010 Cell Cycle
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2‐Chloro‐4,6‐Dimethoxypyrimidine

2010
- Tina Morgan Ross
- Jin-Jun Liu
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Synthesis and activity of quinolinyl-methylene-thiazolinones as potent and selective cyclin-dependent kinase 1 inhibitors

2007 Bioorganic & Medicinal Chemistry Letters
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Biological evaluation of a multi-targeted small molecule inhibitor of tumor-induced angiogenesis.

2006 Bioorganic & Medicinal Chemistry Letters
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Organometallic reagent-mediated one-pot synthesis of 3,5,6-trisubstituted naphthostyrils

2003 Tetrahedron Letters
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