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Martin Morad

University of Pennsylvania
Georgetown University Medical Center
Georgetown University

201

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Mutation in RyR2-FKBP Binding site alters Ca2+ signaling modestly but increases “arrhythmogenesis” in human Stem Cells derived Cardiomyocytes

2021 Cell Calcium
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Characterization of RyR2 Mutations Located at the Caffeine and FKBP Binding Sites in hiPSC-CMs

2020 Biophysical Journal
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Calcium signaling consequences of RyR2 mutations associated with CPVT1 introduced via CRISPR/Cas9 gene editing in human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs): Comparison of RyR2-R420Q, F2483I and Q4201R.

2020 Heart Rhythm
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Probing the RyR2 Ca2+ and Caffeine Binding Sites by Mutagenesis in Human Stem-Cell Derived Cardiomyocytes by CRISPR/Cas9 Gene Editing

2020 Biophysical Journal
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Acid Sensitive Ion channels are expressed in human induced pluripotent stem cell-derived cardiomyocytes

2019 Stem Cells and Development
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CRISPR/Cas9 Engineered Q3925E-RyR2 Mutation in Human Induced Pluripotent Stem Cells Impairs Caffeine Triggered Ca2+ Release

2019 Biophysical Journal
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Cardiac O2 Sensor: A Trio of Hemeoxygenase, CaMKII & Carboxyl Tail of Ca2+ Channel

2019 Biophysical Journal
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Regulation of Ca2+ signaling by acute hypoxia and acidosis in cardiomyocytes derived from human induced pluripotent stem cells

2019 Cell Calcium
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CRISPR/Cas9 Gene editing of RyR2 in human stem cell-derived cardiomyocytes provides a novel approach in investigating dysfunctional Ca2+ signaling

2018 Cell Calcium
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CRISPR/Cas9 Created CPVT1 Associated RyR2 Mutations Reliably Reproduces the Calcium Signaling Aberrancy in Human iPSC-CMS

2018 Biophysical Journal
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