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Xiao-Hua Zhang

Clemson University

19

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188

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Mutation in RyR2-FKBP Binding site alters Ca2+ signaling modestly but increases “arrhythmogenesis” in human Stem Cells derived Cardiomyocytes

2021 Cell Calcium
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Calcium signaling consequences of RyR2 mutations associated with CPVT1 introduced via CRISPR/Cas9 gene editing in human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs): Comparison of RyR2-R420Q, F2483I and Q4201R.

2020 Heart Rhythm
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Acid Sensitive Ion channels are expressed in human induced pluripotent stem cell-derived cardiomyocytes

2019 Stem Cells and Development
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CRISPR/Cas9 Engineered Q3925E-RyR2 Mutation in Human Induced Pluripotent Stem Cells Impairs Caffeine Triggered Ca2+ Release

2019 Biophysical Journal
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CRISPR/Cas9 Gene editing of RyR2 in human stem cell-derived cardiomyocytes provides a novel approach in investigating dysfunctional Ca2+ signaling

2018 Cell Calcium
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CRISPR/Cas9 Created CPVT1 Associated RyR2 Mutations Reliably Reproduces the Calcium Signaling Aberrancy in Human iPSC-CMS

2018 Biophysical Journal
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Generation and Characterization of CPVT1 Cardiomyocytes using Human Induced Pluripotent Stem Cells and CRISPR/Cas9 Gene Editing

2018 Biophysical Journal
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Calcium signaling in human stem cell-derived cardiomyocytes: Evidence from normal subjects and CPVT afflicted patients.

2016 Cell Calcium
- Xiao-Hua Zhang
- Martin Morad
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Regionally diverse mitochondrial calcium signaling regulates spontaneous pacing in developing cardiomyocytes.

2015 Cell Calcium
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Diversity of Mitochondrial Ca (2+) Signaling: Evidence from Genetically Encoded Probes

2015 Biophysical Journal
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