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David L. Lewis

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Safety, Tolerability, and Pharmacokinetics of ARC‐520 Injection, an RNA Interference‐Based Therapeutic for the Treatment of Chronic Hepatitis B Virus Infection, in Healthy Volunteers

2017 Clinical pharmacology in drug development
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Treatment of Chronically HBV-Infected Chimpanzees with RNA Interference Therapeutic ARC-520 LED to Potent Reduction of Viral MRNA, DNA and Proteins without Observed Drug Resistance

2016 Journal of Hepatology
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Chronic hepatitis B: Virology, natural history, current management and a glimpse at future opportunities.

2015 Antiviral Research
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Synthetic RNAi triggers and their use in chronic hepatitis B therapies with curative intent.

2015 Antiviral Research
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Enabling targeted siRNA delivery in vivo using dynamic polyconjugate technology

2009 Journal of Pharmacological and Toxicological Methods
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Systemic siRNA delivery via hydrodynamic intravascular injection

2007 Advanced Drug Delivery Reviews
- David L. Lewis
- Jon A. Wolff
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Transcriptional and phenotypic comparisons of Ppara knockout and siRNA knockdown mice

2006 Nucleic Acids Research
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Mechanism of plasmid delivery by hydrodynamic tail vein injection. I. Hepatocyte uptake of various molecules

2006 Journal of Gene Medicine
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PPARα siRNA–Treated Expression Profiles Uncover the Causal Sufficiency Network for Compound-Induced Liver Hypertrophy

2005 PLOS Computational Biology
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A Facile Nonviral Method for Delivering Genes and siRNAs to Skeletal Muscle of Mammalian Limbs

2004 Molecular Therapy
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Citations (177)