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John Woolfrey

Millennium Pharmaceuticals

14

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321

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Discovery of betrixaban (PRT054021), N-(5-chloropyridin-2-yl)-2-(4-(N,N-dimethylcarbamimidoyl)benzamido)-5-methoxybenzamide, a highly potent, selective, and orally efficacious factor Xa inhibitor.

2009 Bioorganic & Medicinal Chemistry Letters
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Design, synthesis, and SAR of anthranilamide-based factor Xa inhibitors with improved functional activity.

2004 Bioorganic & Medicinal Chemistry Letters
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N, N-Dialkylated 4-(4-arylsulfonylpiperazine-1-carbonyl)-benzamidines and 4-((4-arylsulfonyl)-2-oxo-piperazin-1-ylmethyl)-benzamidines as potent factor Xa inhibitors

2004 Bioorganic & Medicinal Chemistry Letters
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1-(2-Naphthyl)-1H-pyrazole-5-carboxylamides as potent factor Xa inhibitors. Part 3: Design, synthesis and SAR of orally bioavailable benzamidine-P4 inhibitors.

2004 Bioorganic & Medicinal Chemistry Letters
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Design, synthesis, and structure-activity relationships of substituted piperazinone-based transition state factor Xa inhibitors

2003 Bioorganic & Medicinal Chemistry Letters
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Design, synthesis and structure–Activity relationships of benzoxazinone-Based factor Xa inhibitors

2003 Bioorganic & Medicinal Chemistry Letters
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Design, synthesis, and SAR of substituted acrylamides as factor Xa inhibitors.

2002 Bioorganic & Medicinal Chemistry Letters
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Design, synthesis, and SAR of monobenzamidines and aminoisoquinolines as factor Xa inhibitors

2002 Bioorganic & Medicinal Chemistry Letters
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Design, synthesis and biological activity of novel non-amidine factor Xa inhibitors. Part 1: P1 structure–activity relationships of the substituted 1-(2-Naphthyl)-1H-pyrazole-5-carboxylamides

2002 Bioorganic & Medicinal Chemistry Letters
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Design and synthesis of glycolic and mandelic acid derivatives as factor Xa inhibitors

2001 Bioorganic & Medicinal Chemistry Letters
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Citations (14)