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April Chen

AstraZeneca

16

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302

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Pharmacokinetic/Pharmacodynamic Determination and Preclinical Pharmacokinetics of the β-Lactamase Inhibitor ETX1317 and Its Orally Available Prodrug ETX0282.

2020 ACS Infectious Diseases
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Discovery of an Orally Available Diazabicyclooctane Inhibitor (ETX0282) of Class A, C and D Serine β-lactamases.

2020 Journal of Medicinal Chemistry
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Ceftaroline efficacy against high-MIC clinical Staphylococcus aureus isolates in an in vitro hollow-fibre infection model

2017 Journal of Antimicrobial Chemotherapy
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Discovery of Efficacious Pseudomonas aeruginosa-Targeted Siderophore-Conjugated Monocarbams by Application of a Semi-Mechanistic PK/PD Model

2015
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Discovery of Efficacious Pseudomonas aeruginosa-Targeted Siderophore-Conjugated Monocarbams by Application of a Semi-mechanistic Pharmacokinetic/Pharmacodynamic Model

2015 Journal of Medicinal Chemistry
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Pharmacokinetics of the natural antibiotic negamycin

2015 Xenobiotica
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Relationship between Passive Permeability, Efflux, and Predictability of Clearance from In Vitro Metabolic Intrinsic Clearance

2010 Drug Metabolism and Disposition
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Corrigendum to Discovery and optimization of potent and selective triazolopyridazine series of c-Met inhibitors

2010 Bioorganic & Medicinal Chemistry Letters
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from in vitro Metabolic Intrinsic Clearance

2009
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Discovery of AMG 458: A Potent, Selective, and Orally Bioavailable c-Met Inhibitor

2008 Aacr Education Book
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